Malignant glioma is a kind of highly malignant tumor. Since routine therapeutic approaches can only improve the total survival time of the patients with malignant glioma and delay the tumor progression, so the investigation of novel therapies is urgent. With the development of nanotechnology, the nanocarriers for delivering drugs make it possible to transport drugs across the blood brain barrier. Nano drugs delivery system can allow the drugs directly act on the specific targets of malignant glioma combining with rapidly developing targeted therapy strategies, which has improved the therapeutic efficacy of tumor. In this review, we focused on the advances of several nano drug delivery strategies for targeted treating of malignant glioma.