Bladder cancer is one of the malignant tumors that seriously endanger human health, but its diagnosis and treatment progress are relatively slow. With the rapid development of molecular biology and the continuous emergence of biological detection technology, the molecular typing of bladder cancer through gene analysis is expected to become an important means to improve the diagnosis and treatment of bladder cancer. In this paper, we summarized the recent advances in the molecular typing of bladder cancer and its clinical significance in predicting drug responsiveness and judging prognosis.