Objective To explore the application of surgical treatment of hypertensive intracerebral hemorrhage (hICH) in patients with long-term oral aspin administration; Methods: In this retrospective study, we included 10 (hICH) patients with long-term oral aspin administration who were treated with operation in Neurosurgical Department of Changzheng Hospital of Second Military University from Aug. 2014 to Aug. 2016. Data Concerning patients’ clinical demographics as well as 3-month follow up were collected. Surgical procedures and effects for hICH were analyzed together. Results: 5 patients underwent craniotomy, among which 3 were conducted by emergency operation. There 3 patients had difficulties in surgical hemostasis and 2 of them suffered rebleeding after operation. All of these patients survived in 3-month follow-up with Glasgow Outcome Scale (GOS) between 2-4. 5 patients had emergency drainage for hematoma and the blood was easy to drain out. 2 patients died in 14 and 37 days, and the rest had a GOS of 2 in 3 months. Conclusion: hICH patients with long-term oral aspin administration tended to have larger hematoma volume. Aspin should be stopped and it’s favorable to have blood transfusion before individualized surgery.