Biomedical Informatics Research Center,Shanghai Children’s Hospital,Shanghai Jiao Tong University,Biomedical Informatics Research Center,Shanghai Children’s Hospital,Shanghai Jiao Tong University,Department of Child Healthcare,Shanghai Children’s Hospital,Shanghai Jiao Tong University,Biomedical Informatics Research Center,Shanghai Children’s Hospital,Shanghai Jiao Tong University,Biomedical Informatics Research Center,Shanghai Children’s Hospital,Shanghai Jiao Tong University,Biomedical Informatics Research Center,Shanghai Children’s Hospital,Shanghai Jiao Tong University

Supported by Leading Scientist Plan of Shanghai Science and Technology Commission (18XD1403200), Project of Shanghai Big Data Engineering and Technology Research Center for Pediatric Precision Medicine, Special Fund from Shanghai Science and Technology Committee (17DZ22512000), Scientifc Research Project of Health and Family Planning Commision of Shanghai (2018ZHYL0223), and Scientifc Research Project for Young Scientists of Health and Family Planning Commision of Shanghai (20144Y0179).