Objective To explore local surgical excision of duodenal gastrointestinal stromal tumor (GIST) and the way of digestive tract reconstruction, and to summarize our clinical experience. Methods The clinical data of 29 patients with duodenal GIST who underwent local resection from Jan. 2010 to Jan. 2018 in the Department of Anorectal Surgery of our hospital were included for study. The local resection methods and the reconstruction of digestive tract were analyzed, and the clinical efficacy and indications of different local resection methods were discussed while considering the clinicopathological parameters and follow-up data. Results We found that 24 (82.8%) cases had their lesions located in the bulb and descending part of the duodenum and 5 (17.2%) cases in the horizontal and ascending part of the duodenum. Nineteen cases underwent simple wedge resection and one-stage anastomosis (16 cases underwent open surgery and 3 cases underwent laparoscopic surgery), 7 cases underwent open segment resection+Billroth Ⅱ gastrojejunostomy+Roux-en-Y anastomosis, 2 cases underwent open wedge resection+Roux-en-Y duodenojejunostomy, and 1 case underwent open segment resection+duodenojejunostomy lateral anastomosis. Postoperative pathology showed that all patients had negative resection margin (R0). Anastomotic fistula occurred in 2 cases and intestinal obstruction in 3 cases. No local recurrence was noticed during the follow-up. Conclusion Local excision is a reasonable choice for duodenal GIST, with reliable curative effect.