Objective To evaluate the safety of modern rigid bronchoscopy related therapeutic procedures. Methods We retrospectively analyzed the clinical data of 100 patients with benign or malignant lesions who underwent modern rigid bronchoscopy operation between Apr. 2014 to Apr. 2016 at Respiratory Endoscopy Center of Changhai Hospital, Naval Medical University (Second Military Medical University). A total of 124 rigid bronchoscopy operations were performed. The intraoperative complications of rigid bronchoscopy were analyzed. Results The intraoperative complications of rigid bronchoscopy were as follows:transient hypoxemia (4.03%, 5/124), injury of vocal cords and around mucosae (4.84%, 6/124), exposure keratitis (1.61%, 2/124), airway structural failure (2.42%, 3/124), damage of electronic bronchoscope (2.42%, 3/124), and insertion failure of rigid bronchoscopy (0.81%, 1/124). There were no deaths during operation. Conclusion Modern rigid bronchoscopy is a treatment technique with high safety and few complications, and is worthy of clinical promotion and application. Standardized rigid bronchoscopy operation and related technique training should be carried out to improve its safety and reduce complications.