Objective To explore the application value of bi-pedicle flap in the repair of complex soft-tissuedefect wounds. Methods From Jan. 2014 to Dec. 2018, 92 patients with soft-tissue-defect caused by tumors or traumatic factors were treated with bi-pedicle flap transplantation in Burn and Trauma Surgery Department of Changhai Hospital, Naval Medical University (Second Military Medical University). The clinical and surgical data were observed and recorded, including the pathogenesis, location, ratio of length to width and covering area of the flap, management of flap donor area, preservation of perforator vessels, surviving rate of the flap, and secondary transplantation rate. Results Of the 92 patients receiving bi-pedicle flap transplantation, 49 cases were caused by tumor resection, 36 cases were caused by trauma (17 cases of bone exposure, 12 cases of internal fixation exposure and 7 cases of tendon exposure), and 7 cases were caused by other reasons (5 cases of pressure sore and 2 cases of electric burn). The locations of tissue defects were crus (28 cases), ankle (16 cases), thigh (14 cases), trunk (12 cases), upper limb (11 cases), hip (6 cases), and foot (5 cases). The ratio of length to width of the flap was 1.2-2.8, and the average covering area was (16.55±4.83) cm×(9.88±4.20) cm. There were 43 cases of direct suture of flap donor area, 26 cases of delayed suture and 23 cases of skin-graft. In nine patients, the perforating branches of the musculocutaneous vessels were preserved during the separation due to the large transfer span, area and length-width ratio of the flap. Twenty-one days after surgery, the bi-pedicle flap in 89 patients survived completely, and that in 3 cases had a little necrosis on the edge. After removing the necrotic tissues, the bi-pedicle flap was closed and sutured. In nine patients, there were residual wounds in the flap donor area, and the secondary skin grafting was performed. Conclusion The bi-pedicle flap has the advantages of simple operation, reliable survival, less trauma and direct or delayed suture of partial flap donor areas, and it has great potentials in the repair of complex soft-tissue-defect wounds caused by tumors or trauma.