Objective To evaluate the application value of ultrasound-guided superficial cervical plexus block positioned by great auricular nerve in clavicle surgery. Methods A total of 100 patients who were scheduled to undergo clavicular surgery were enrolled in this study after the great auricular nerve was confirmed by ultrasound and transcutaneous electrical stimulation. The patients were randomly assigned to two groups:routine ultrasound-guided group and great auricular nerve-positioned group, with 50 cases in each group. A mixture of 1% lidocaine and 0.375% ropivacaine was used for local anesthesia. In the routine ultrasound-guided group, nerve block was performed by skin puncture at the midpoint of the sternocleidomastoid muscle posterior margin (from the attachment point of the clavicular head to the most prominent point of the mastoid process). In the great auricular nerve-positioned group, relevant morphological data were measured before puncture, and then nerve block was performed by skin puncture at the great auricular nerve puncture point under ultrasound guidance. Pinprick test was used to evaluate the blocking effect and the adverse events were recorded. Results There were no significant differences in age, gender, body mass index (BMI) or operation time between the two groups (all P>0.05). In the great auricular nerve-positioned group, the average current intensity to elicit positive reaction of great auricular nerve was (1.1±0.3) mA, and mean time from start of scan to completion of marking of the great auricular nerve puncture point was (30.5±8.2) s. In the great auricular nerve-positioned group, the puncture sites of 94% (47/50) patients were coincident or caudal to the routine ones, only 3 patients' puncture sites were cranial to the routine ones, with average distance between the two points being (1.27±0.84) cm. The success rate of nerve blocking was significantly higher in the great auricular nervepositioned group than that in the routine ultrasound-guided group (98.0%[49/50]vs 78.0%[39/50], P<0.05), and the great auricular nerve-positioned group had a faster onset. At 24 h of post-operative observation, one patient in each group had hoarseness after block, and no other adverse events or complications occurred. Conclusion Ultrasound-guided superficial cervical plexus block positioned by great auricular nerve has the advantages of rapid onset, high success rate, and few complications.