Coronavirus disease 2019 (COVID-19) outbreak as a public health emergency leads to panic, anxiety and other stress reactions among the frontline rescue workers and the general public. The mental health problems under the epidemic can not be ignored. We adopted a new comprehensive millitary mental stress rescue mode of “front+rear, online+ offline, front-line psychological screening interview+rear team intervention and counseling, psychological consultation+psychiatric drugs, psychological counselor+network engineer” to provide psychological intervention and psychological guidance for medical and rescue workers in Wuhan. The new comprehensive millitary mental stress rescue mode played an important role in reducing the rescue support investment and the risk of COVID-19 infection among psychological rescue workers, which could be widely used in the process of stress rescue.