Long non-coding RNA (lncRNA) was once considered to be the "noise" of genome transcription without biological function. In recent years, increasing evidence shows that lncRNA is dynamically expressed at different developmental stages or disease statuses and plays a regulatory role in gene expression and translation. In particular, the effectiveness of lncRNA has been proven in gene regulation of cardiac development. It also participates in multiple pathological changes of heart failure such as cardiac hypertrophy, fibrosis, angiogenesis, etc. Therefore, lncRNA is considered to be the core hub of complex regulatory networks controlling cardiac physiology and pathology, and is expected to become a therapeutic target for heart failure. This article reviews the role and mechanism of lncRNA in heart failure, and evaluates its prospects in the future clinical diagnosis and treatment.