The coronavirus disease 2019 is a highly infectious disease, and the spread of the virus affects the normal diagnosis and treatment of medical facilities. It has brought great difficulties to some patients with oral diseases, and has aggravated their psychological and mental burden, especially those children who are susceptible to external influences and parents who are in lack of related knowledge. This paper comprehensively analyzes the psychological changes of children and their parents in stomatology department during the epidemic period, so as to provide effective psychological counseling and nursing intervention to improve the cooperation between doctors and patients and the quality of diagnosis and treatment.