Construction and evaluation of experimental models of neovascular eye diseases
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R77

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Supported by National Natural Science Foundation of China (81700839), China Postdoctoral Science Foundation (2018M632122), and Shanghai Chenguang Project (18CG40).

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    Abstract:

    Angiogenesis is a complex process playing important roles in growth and development, tissue and organ regeneration, and many pathological changes. Pathological angiogenesis in the eye is the main feature of neovascular eye diseases, which can lead to visual loss or even blindness. Therefore, experimental models of neovascular eye diseases are very important for the development of antiangiogenic therapy. This paper reviews the commonly used experimental models of neovascular eye diseases and their quantitative evaluation, and analyzes their advantages and limitations, helping researchers to choose the most appropriate models for their studies.

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History
  • Received:June 30,2020
  • Revised:August 21,2020
  • Adopted:
  • Online: May 08,2021
  • Published:
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