Objective To explore the correlation between ⁶⁸Gallium-prostate-specific membrane antigen (⁶⁸Ga-PSMA)-11 positron emission tomography-computed tomography (PET-CT)-derived metabolic volume parameters and clinical indicators of patients with newly diagnosed prostate cancer (PCa). Methods The imaging and clinical data of untreated 85 patients with PCa diagnosed by prostate biopsy who underwent ⁶⁸Ga-PSMA-11 PET-CT in Changhai Hospital, Naval Medical University (Second Military Medical University) from Jan. to Dec. 2019 were retrospectively analyzed; 46 patients without tumor metastasis were included in the non-metastasis group and 39 with tumor metastasis in the metastasis group. Spearman rank correlation test was performed to analyze the correlation between metabolic volume parameters (primary tumor maximum standardized uptake value[SUV_max], mean standardized uptake value[SUV_mean] of primary tumor, total lesion of prostate-specific membrane antigen[TL-PSMA]) and clinical indicators (age, body mass index, Gleason score[GS], and prostate-specific antigen[PSA]) of the two groups. Results In the non-metastasis group, PSA was moderately positively correlated with primary tumor SUV_max and primary tumor TL-PSMA (r_s=0.409, P=0.005; r_s=0.587, P<0.001), while GS was not correlated with primary tumor SUV_max and primary tumor TL-PSMA (r_s=0.181, P=0.229; r_s=0.101, P=0.505). In the metastasis group, PSA was moderately positively correlated with primary tumor TL-PSMA, metastasic tumor TL-PSMA and whole-body TL-PSMA (r_s=0.439, P=0.005; r_s=0.588, P<0.001; r_s=0.569, P<0.001), but not correlated with primary tumor SUV_max (r_s=0.255, P=0.117); while GS was not correlated with primary tumor SUV_max, primary tumor TL-PSMA, metastasic tumor TL-PSMA and whole-body TL-PSMA (r_s=0.069, P=0.675; r_s=0.194, P=0.237; r_s=0.299, P=0.064; r_s=0.300, P=0.063). Conclusion The metabolic volume parameter TL-PSMA, which reflects the systemic tumor burden in patients with newly diagnosed PCa, is positively correlated with serum PSA, but not with GS, which reflects the differentiation degree of primary tumor.