Objective To investigate the positive findings of ⁶⁸gallium-labelled prostate-specific membrane antigen (PSMA) ligand PSMA-11 (⁶⁸Ga-PSMA-11) positron emission tomography-computed tomography (PET-CT) in patients with newly diagnosed prostate cancer. Methods The imaging and clinical data of 45 patients with prostate cancer newly diagnosed by biopsy who undergoing ⁶⁸Ga-PSMA-11 PET-CT in Changhai Hospital of Naval Medical University (Second Military Medical University) from Jan. to Dec. 2019 were retrospectively analyzed. The ⁶⁸Ga-PSMA-11 PET-CT images were qualitatively analyzed by binomial classification to observe the involvement of prostate bilobes, capsule, seminal vesicles and regional lymph nodes. With the pathology result of radical prostatectomy as the gold standard, the McNemar test of image-pathology paired samples was carried out, and the Kappa coefficient was calculated. Results The accuracy rates of ⁶⁸Ga-PSMA-11 PET-CT in detecting primary lesions involving prostate bilobes, capsule, seminal vesicles and regional lymph nodes were 60.0% (27/45), 57.8% (26/45), 75.6% (34/45) and 84.4% (38/45), respectively, and the Kappa coefficients were 0.075 (P=0.375), 0.249 (P=0.025), 0.409 (P=0.003) and 0.444 (P=0.002), respectively. Conclusion ⁶⁸Ga-PSMA-11 PET-CT has a value in detecting involvement of seminal vesicles and regional lymph nodes in patients with newly diagnosed prostate cancer, but has a low value in detecting involvement of prostate bilobes and capsule.