G protein-coupled receptor (GPCR) is the largest receptor family on cell surface, it is widely distributed in organs and tissues such as the central nervous system, immune system, cardiovascular system, and retina, and participates in body development and normal function. Liver is an important organ of human body and has many functions such as metabolism, detoxification, and secretion and excretion of bile. GPCRs in the liver are involved in many pathophysiological processes. This article reviews the research progress of GPCRs involved in acute and chronic liver injury.