Pancreatoduodenectomy is one of the largest surgeries in abdominal surgical field, with a high incidence of postoperative complications. Postoperative pancreatic fistula (POPF)-related hemorrhage is one of the most fatal and severe complications after pancreatoduodenectomy. The risk factors of POPF-related hemorrhage include pancreatic duct size, pancreatic texture, vascular pseudoaneurysm, pancreaticojejunostomy leak, choledochojejunostomy leak, and so on. The management and prevention are of great importance to POPF-related hemorrhage, and it is the goal that pancreatic surgeons are striving for. This review provides an overview of the risk factors, prevention and treatment strategies, and research progress of POPF-related hemorrhage after pancreatoduodenectomy.