Non-surgical treatment of breast diseases is the characteristic and advantage of traditional Chinese medicine (TCM). In the long-time clinical practice, Zhao's TCM clinic in Baoji, Shaanxi, insisted on the combination of internal and external treatment for breast diseases and has achieved satisfactory results. In the internal treatment, the Zhao's highlighted that "depression" is the core pathogenesis throughout the whole process of breast diseases. Guided by the theory of "smoothing the collaterals of the breast is the most important", the Zhao's developed a series of treatments and prescriptions focusing on "relieving depression", which improved the treatment efficacy of various breast diseases. In addition, for breast diseases, Zhao's TCM surgery attaches great importance to the external treatment, and has developed many external drugs represented by "Zhao's Yibixiao Gao". The combination of internal treatment and external treatment shows a remarkable effect for breast diseases. Hoping to make our own contribution to TCM diagnosis and treatment for breast diseases and the inheritance of TCM, this article introduces Zhao's thinking of combining internal and external treatments for breast diseases and demonstrates the clinical efficacy of Zhao's treatment for 3 common breast diseases, namely, breast carbuncle, mammary hyperplasia, and breast rock.