Therapeutic drug monitoring (TDM) is crucial for preserving vancomycin efficacy and avoiding adverse effects, and it is helpful to develop individualized dosing regimens. With the update of China and US criteria for TDM indexes, the TDM guided by the area under the 24 h drug-time curve (AUC_{24 h}) has gradually become a focus. Compared with trough concentration-guided TDM, AUC_{24 h}-guided TDM can decrease the incidence of vancomycin-induced acute kidney injury. Clinical implementation of AUC_{24 h}-guided TDM is possible using Bayesian and linear pharmacokinetic techniques. Both approaches can achieve AUC_{24 h} prediction and provide early intervention. It is essential for healthcare organizations to select appropriate methods of monitoring based on their actual situation.