Due to the influence of objective environmental stimuli, individuals in isolated and confined environments (ICE) are prone to negative emotions and stresses, resulting in a strong sense of isolation and separation. Therefore, studying the impact of long-term ICE tasks on individual mental health and the methods and mechanisms of psychological regulation are beneficial for improving the psychological health level of the members and helping them better adapt to the environment to complete tasks. By analyzing the individual coping strategies, adaptation skills, emotional regulation, and team management for ICE, the psychological regulation of long-term ICE tasks can be roughly summarized into 3 stages: pre task preparation, in task support, and post task readjustment. Using psychological health checklists, isolated and confined extreme-questionnaire and other scales for monitoring, implementing strategies to promote positive emotions and task orientation, allowing a mediating role in resilience, cultivating appropriate humor, and effective communication and conflict management among teams are all important ways to adapt to ICE.