Hepatobiliary and pancreatic tumors are high-incidence diseases of the digestive system with high malignancy and poor clinical prognosis. Failure to achieve radical resection and sufficient dissection of lymph nodes during surgical treatment is the main reason for tumor recurrence and metastasis. Indocyanine green (ICG) fluorescence staining has been commonly used in the detection of liver function and the evaluation of effective liver blood volume in the past. In recent years, it has been gradually applied to the intraoperative diagnosis, treatment and monitoring of hepatobiliary and pancreatic tumor metastases, in order to achieve better radical results of surgery. This paper reviews the application of ICG fluorescence staining in hepatobiliary and pancreatic tumor metastases based on related literatures.