Pain is the most common and severe symptom of endometriosis. However, there is no effective treatment nowadays, and the mechanism of endometriosis pain remains poorly defined. Mast cells are immune cells that can interact with sensory nerves to induce endometriosis pain. Recent studies have shown that mast cells play a vital role in the development of endometriosis pain. This article summarizes the latest research to highlight advances in mast cells involving in endometriosis pain through inflammatory response, angiogenesis, nerve growth, and peripheral and central sensitization, hoping to provide new ideas for the mechanism research and clinical treatment of endometriosis pain.