Objective To explore the feasibility and safety of fastest recovery after surgery (FRAS) in laparoscopic surgery of gastrointestinal tumors. Methods The clinical data of patients undergoing laparoscopic surgery for gastrointestinal tumors under FRAS and enhanced recovery after surgery (ERAS) from Jan. 2023 to May 2024 were collected, and perioperative safety and medical cost were analyzed. Results A total of 87 patients were enrolled, including 43 in the FRAS group and 44 in the ERAS group. Compared with the ERAS group, the FRAS group had significantly shorter surgical time (3.0 ［2.5, 3.5］ h vs 3.0 ［2.5, 4.0］ h), first postoperative movement time (［2.85±4.29］ h vs ［20.18±6.13］ h), first postoperative oral feeding time (2.0 ［2.0, 3.0］ h vs 24.0 ［15.0, 48.0］ h), postoperative hospital stay (24.0 ［20.0, 40.0］ h vs 192.0 ［150.0, 216.0］ h), lower hospitalization costs (50 515.61 ［46 650.44, 56 827.12］ yuan vs 65 555.09 ［58 683.21, 86 239.02］ yuan), and lower medication costs (2 671.09 ［2 063.31, 3 127.09］ yuan vs 7 326.90 ［5 104.66, 10 674.26］ yuan) (all P＜0.05). Conclusion It is safe and feasible to use FRAS during the perioperative period of laparoscopic radical gastrectomy for gastrointestinal tumors, and FRAS can also reduce the costs of hospitalization and medications.