Skeletal system and immune system are 2 important systems for maintaining human life. Osteoporosis is a complex pathological change of bone tissue. Immune system disorders have become the cause of osteoporosis through affecting the proliferation and differentiation of osteoblasts and osteoclasts. Innate immunity, adaptive immunity, and cytokines play crucial roles in bone resorption and remodeling by regulating the signaling pathways of osteoblasts and osteoclasts. Therefore, immunoporosis has emerged for studying the inseparable relationship between osteoporosis and immune system. This article reviews the research progresses on immunoporosis, aiming to provide references for immunotherapy of osteoporosis.