Objective: To study the characteristics of collagen and the preparation of poly-hydroxyethyl methacrylate (HEMA)-collagen membrane. Methods: TypeⅢ collagen extracted from calf fetus skin was mixed thoroughly with HEMA and ethylene glycol. The polymerization was induced by ammonium persulfate and sodium metabisulfite. Results: The poly(HEMA)-collagen membrane was an elastic, flexible, absorbent and adhesive film. The cumulative in vitro release profile of indometacin from the membrane showed that the porous sponges could be used as a good drug release system. Conclusion: The poly(HEMA)-collagen membrane is a good material to be used as a wound dressing for burns.