Objective: To discuss the therapeutic effect of immunosuppresant for adult polycystic kidney disease (APDK). Methods: Collecting 24 cases of APKD patients undergone the renal transplantation for 1-8 years (mean time is 3.18 years). The checking items were waist pain,haematuria,hypertension and polycystic kidney size before and after renal transplantation. Immunosuppressants include cyclosporine, azathioprine and prednisone. Results: After transplantation, release of waist pain was most obvious; occurrence rate of haematuria decreased from 83.3%to 12.5%(P<0.01); hypertention did not change in 1 month but improved in 1 year (P<0.01); polycystic kidney size examined by B-ultrasound showed no difference and stayed in “steady” state. Conclusion: Immunosuppressants contribute to all the above improvements. APKD may be gene-depended immunodisease or immunity plays an important role in its pathogenesis. So immunosuppressant may be therapeutically effective for APKD.