Objective:To determine calcitonin gene related peptide (CGRP) levels in cord plasma and amniotic fluid of pregnancy induced hypertension (PIH) patients. Methods: CGRP levels in cord plasma and amniotic fluid of 26 normal pregnant women (NP group) were measured with radioimmunoassay (RIA).Results: Plasma CGRP levels in umbilical artery of PIH patients were significantly higher than that of NP women (P＜0.01),and it increased as the disease became worse, the severe increased markedly when compared with the mild (P＜0.05).CGRP levels in amniotic fluid of PIH patients were significantly higher than that of NP women(P＜0.05).There was a negative correlation between neonatal 1 min Apgar Scores after delivery and CGRP levels in umbilical artery(P＜0.01),as well as that in amniotic fluid(P＜0.05).Conclusion: The changes of CGRP levels in umbilical artery and amniotic fluid are correlated with intrauterine fetal distress