Objective: To study the relation between medicine consumption and the injury severity. Methods: The use of medicine and the injury conditions of soldiers in the rear hospital in the Two Mountains Fight were investigated. And the Abbreviated Injury Scale and Injury Severity Score(AIS-ISS) was applied to quantify the condition of the injuries. Defined Daily Dose(DDD) was introduced as the consumption unit. Results: Analyzed by SAS software, the model between ISS(X) and DDDs(Y) was established: Y=16.99lnX-0.53. r2=0.663 7, P＜0.01.It showed that in the particular scope of ISS, the frequency of antibiotics administration rose up with the increase of the injury severity, and it tended to saturate as the severity went worse. Conclusion: For the first time ISS is used to analyze medical supplies consumption, the multi-factors are transformed into mono-factor affecting medical supplies in wartime. It is a good solution to the problem of how to measure injury severity. The general rule of medicine consumption is discovered in rear hospital. The method is easy use.