Objective： To evaluate the antiinflammatory and antioxidant effects of the extracts of Scrophularia ningpoensis Hemsl. (SN) in vivo and in vitro. Methods: (1) Carrageenan and cobra venom induced rat paw edema； (2) Fe2+/cystine induced rat liver microsomal lipid peroxidation and (3) 2,2′-azobis(2-amidinopropane) dihydrochloride (AAPH) induced oxidative hemolysis were used to study the effects of the extracts from SN. Results: The crude extract of SN had more potent antiinflammatory effect in vivo. At a dose corresponding to the quantity contained in the crude extracts, the phenylpropanoid glycosides had potent antioxidant effects, while the iridoid glycosides of SN had lower antioxidant activities. Conclusion: The antiinflammatory activity of SN appears to have some relationship with the antioxidant effect of phenylpropanoid glycosides.