Objective: To investigate the effect of astragalus saponins on mice myocarditis caused by CVB3. Methods: Male BALB/c mice was inoculated i.p. with 1000 TCID50 CVB3 and administered 5.64× 10-3 mg/g astragalus saponins i.p. for 7d starting 1 h after viral inoculation. The survial rate,the body temperature, LDH and GOT,the heart histopathologic changes,the virus titer of heart were observed. Results: The survival rate was higher, LDH and GOT release was lower, the body temperature was higher and similar to normal mice, the virus titer of heart was lower, the heart mass/body mass ratio was lower, the histopathologic changes (necrosis, degeneration and cellular infiltration) was lighter in astragalus saponins treated group than in viral control group. The statistic is valuelar. Conclusion: Astragalus saponins has therapeutic effects on viral myocarditis. The machenism may be anti-viral, improving of circulation and lightening of myocardial injury