Objective：To evaluate the relationship between serum AGE and diabetic chronic complication (DCC). Methods: Serum AGE in diabetic patients was measured by competitive ELISA. Results: Both of 15 diabetic patients with DCC and 11 diabetic patients without DCC had higher mean serum AGE concentrations than that of normal group (P＜0.01). Conclusion: This may be the increasing production of endogenous AGE that the diabetic group had a higher mean serum AGE than normal group,serum AGE may provide an indicators of long term blood glucose control and predict the occurances of diabetic chronic complications.