Abstract:Machine learning is a powerful data analysis technique that can collect and analyze massive data and hidden information, solving the problems of comprehensive diagnosis of multidimensional data, and personalized intervention and treatment, which is urgently needed in the field of mental health. This paper reviews the application of machine learning in diagnosis, treatment, and prognosis of mental health. We also introduced the advantages prospect of the technology in 2 dimensions (big and small), and analyzed the possible risks and challenges in the field.

Abstract:Objective To explore the application value of swelling hemostatic materials in the first aid of war trauma. Methods Polyvinyl alcohol (PVA) and polyether ester-ethyl carbamate (PEEC) were placed in normal saline, anticoagulant rabbit blood, and 1∶1 mixture of normal saline and anticoagulant rabbit blood to evaluate their physical properties in vitro. The volume, weight changes, and pressure required for half volume compression of the 2 swelling hemostatic materials were recorded. A rat femoral arteriovenous injury model and a rabbit liver injury model were established to evaluate the hemostatic performances of PVA and PEEC in vivo. The hemostatic effects of sterile gauze, PVA, and PEEC on bleeding after femoral arteriovenous injury and liver injury were observed. The blood loss at 1 h and 24 h after operation, the blood loss at 1 min after removing the hemostatic materials, the degree of adhesion and the removal difficulty were observed and recorded. Results The volume change coefficient and volume change rate of PVA in the 3 simulated body fluids were higher than those of PEEC, while the weight change coefficient was lower than that of PEEC (all P＜0.01). In normal saline and anticoagulant rabbit blood, the pressures required for PVA to compress half of its volume were lower than that required for PEEC (both P＜0.05). One hour after surgery, the degree of adhesion and difficulty of removing PVA were better than those of sterile gauze and PEEC in the 2 animal models. One minute after removing the hemostatic materials, only the sterile gauze group showed a small amount of bleeding, while no active bleeding was observed in the PVA or PEEC group. In the femoral arteriovenous injury bleeding model, the blood loss at 1 h after surgery in the PVA group was less than that in the PEEC group (P＜0.01), while in the liver injury bleeding model, the blood loss at 1 h after surgery in the PVA group was more than that in the PEEC group (P＜0.01). At 24 h after surgery, the degree of adhesion and difficulty of removing PVA were better than those of sterile gauze, while most of PEEC was degraded and could not be removed. One minute after removing the hemostatic materials, no active bleeding was observed in the sterile gauze, PVA, or PEEC group. In the femoral arteriovenous injury bleeding model, there was no significant difference in the blood loss at 24 h between the sterile gauze group and the PVA group (P＞ 0.05). In the liver injury bleeding model, the blood loss at 24 h in the PVA group was more than that in the sterile gauze group (P＜0.01). In the 2 animal models, the blood loss at 24 h in the PEEC group was small, and it could not be calculated. In the femoral arteriovenous injury bleeding model, there were fewer inflammatory cells infiltrating around the muscle tissue near the hemostatic materials in the PVA group than in the sterile gauze and PEEC groups. Conclusion Both PVA and PEEC can control bleeding after femoral arteriovenous injury or liver injury by absorbing body fluids (including blood) to enlarge their own volume, providing new choices for the research and development of new equipment for the first aid of war trauma.

Abstract:Objective To investigate and analyze the disease spectrum of hospitalized naval officers and soldiers, so as to provide reference for their health management and medical support. Methods The disease spectrum of hospitalized naval officers and soldiers was analyzed based on the front page data of medical records collected from 6 hospitals in a region between 2013 and 2017. The principal discharge diagnoses of inpatients were classified and statistically analyzed according to the International Classification of Diseases (ICD)-10. Results A total of 21 177 hospitalized diagnosis and treatment data of naval officers and soldiers were included, and the top 10 diagnostic categories accounted for 85.98% (18 208/21 177). In the major diagnostic categories of inpatients, circulatory system diseases (14.79%, 3 132 cases), digestive system diseases (14.59%, 3 090 cases), respiratory system diseases (14.06%, 2978 cases), and genitourinary system diseases (9.94%, 2 104 cases) ranked the top 4. Common diseases under the top 4 major diagnostic categories included chronic ischemic heart disease (21.87%[685/3 132］), acute appendicitis (16.38%[506/3 090］), pneumonia (pathogen unspecified) (19.21%[572/2 978］), and kidney and ureteral calculus (20.77%[437/2 104］). The disease spectrum of hospitalized naval officers and soldiers of different genders and ages displayed different characteristics. Conclusion Circulating system diseases, digestive system diseases, respiratory system diseases, and genitourinary system diseases are the main types of diseases of hospitalized naval officers and soldiers. The abilities of diagnosing and treating and prevention and control education should be strengthened for the above major diagnostic categories and corresponding common diseases.

Abstract:Objective To analyze the characteristics of 5-year population metabolic indexes of military medical personnel in a tertiary hospital, so as to provide reference for optimizing the health management of metabolic diseases in this population. Methods The health records of military medical personnel in a tertiary hospital from 2016 to 2020 were collected. SPSS 21.0 software was used to analyze the abnormal metabolic indexes and group characteristics. Results The metabolic indexes with high abnormal rates among military medical personnel from 2016 to 2020 were overweight, uric acid (UA), and low-density lipoprotein cholesterol (LDL-C), and the differences in the abnormal rates of UA and LDL-C were significant over the past 5 years (χ²=21.797, P＜0.01; χ²=10.521, P＜0.05). The indexes with higher abnormal rates in males were overweight, LDL-C, and UA, while the indexes with higher abnormal rates in females were LDL-C and total cholesterol (TC). In the comparison of the 5-year abnormal rates of a single index in the same gender group, there were significant differences in the abnormal rates of UA and LDL-C in males (χ²=45.496, P＜0.01; χ²=12.086, P＜0.05) and in the abnormal rates of UA, TC, and LDL-C in females (χ²=10.270, P＜0.05; χ²=14.349, P＜0.01; χ²=10.834, P＜0.01). The 5-year abnormal rates of overweight, UA, TG, and high-density lipoprotein cholesterol in males were higher than those in females (all P＜0.05). From 2016 to 2020, there were significant differences in the abnormal rates of fasting blood glucose (FBG) and LDL-C among the ＜40, 40-50, and ＞50 years old groups (all P＜0.01), the abnormal rate of FBG was the highest in the ＞ 50 years old group in 5 years, and the abnormal rate of LDL-C in the ＞50 years old group was the highest from 2017 to 2020. The difference in the overweight rate among the 40, 40-50, and ＞50 years old groups in 2020 was significant (P＜0.01), and the ＞50 years old group had the highest overweight rate. Conclusion The changes of metabolic indexes of military medical personnel have certain group characteristics, and gender and age have impacts on the abnormal rates of metabolic indexes.

Abstract:Objective To analyze the depression and its influencing factors among elderly hypertensive patients in China based on the 8^th round Chinese Longitudinal Healthy Longevity Survey (CLHLS) data. Methods A total of 5 210 hypertensive patients aged ≥65 years having survey results of 10-item Center for Epidemiologic Studies depression scale (CES-D-10) were enrolled according the 8^th round CLHLS data. The depression was identified by the total score of CES-D-10≥10. Covariates such as demographic characteristics, social factors, living habits, and health status were included. Multiple imputation was used to fill in the missing data, and binary logistic model was used to analyze the influencing factors of depression of elderly people with hypertension. Results The prevalence of depression among the 5 210 elderly people with hypertension was 12.84% (669/5 210). The logistic regression analysis showed that male (odds ratio[OR］＝1.355), poor (OR= 3.132), and activities of daily living (ADL) dysfunction (mild: OR=1.894; severe: OR=2.951) were risk factors of depression in the elderly people with hypertension, while age≥90 years old (90-99 years old: OR=0.527; ≥100 years old: OR=0.517), being rich (OR=0.701), doing exercise (OR=0.551), and long sleep duration≥6 h (6.0-7.9 h: OR=0.286; 8.0-9.9 h: OR= 0.203; ≥10.0 h: OR=0.205) were protective factors (P＜0.05). Conclusion Depression is found in 12.84% of elderly patients with hypertension. The elderly patients with hypertension, who are male, age＜90 years old, with low income and ADL dysfunction, and sleep time＜6 h, without physical exercise habits, are more likely to have depression.

Abstract:Objective To explore the risk factors of poor prognosis of anterior circulation acute ischemic stroke with large-vessel occlusion (AIS-LVO) patients after endovascular therapy (EVT), so as to determine the predictive value of D-dimer for poor prognosis of anterior circulation AIS-LVO patients after EVT. Methods Anterior circulation AIS-LVO patients who received EVT and hospitalized in the Department of Neurology, Hebei General Hospital from Dec. 2018 to Dec. 2022 were enrolled. According to the 90-d modified Rankin scale (mRS) score after operation, they were assigned to good prognosis group (mRS score of 0-2) or poor prognosis group (mRS score of 3-6). Preoperative Alberta Stroke Program early computed tomography score (ASPECTS), preoperative National Institutes of Health stroke scale (NIHSS) score, preoperative Glasgow coma scale score, immediate postoperative modified thrombolysis in cerebral infarction (mTICI) grade, general data, and laboratory data of anterior circulation AIS-LVO patients were collected. Binary logistic regression was used to analyze the influencing factors of poor prognosis in anterior circulation AIS-LVO patients after EVT, and receiver operating characteristic (ROC) curve was used to evaluate the predictive value of D-dimer for poor prognosis. Results A total of 143 patients with anterior circulation AIS-LVO undergoing EVT were enrolled, with 54 patients in the poor prognosis group and 89 in the good prognosis group. Compared with the poor prognosis group, patients in the good prognosis group had younger age, lower proportion of diabetes mellitus, lower preoperative NIHSS score, higher preoperative ASPECTS and Glasgow coma scale score,higher proportion of immediate postoperative mTICI grade 2b-3, and lower preoperative D-dimer level (all P＜0.05). Binary logistic regression analysis showed that preoperative NIHSS score (odds ratio[OR］＝1.096, 95% confidence interval[CI］ 1.007-1.193), immediate postoperative mTICI grading (OR=19.609, 95% CI 5.354-71.815) and preoperative D-dimer level (OR=1.310, 95% CI 1.128-1.521) were independent risk factors for poor prognosis in anterior circulation AIS-LVO patients receiving EVT. The area under the ROC curve value of D-dimer for the the poor prognosis of anterior circulation AIS-LVO patients after EVT was 0.642 (95% CI 0.54-0.745). Conclusion Preoperative NIHSS score, immediate postoperative mTICI grading and higher preoperative D-dimer level are independent risk factors for poor prognosis in anterior circulation AIS-LVO patients after EVT. AIS-LVO patients with elevated D-dimer levels before surgery may have a poor prognosis after EVT.

Abstract:Objective To evaluate whether peripancreatic necrosis volume (PNV) is a useful index for predicting the severity of acute pancreatitis (AP), and to compare the predictive value of PNV with the current clinical scoring system and 48 h-Creactive protein (48 h-CRP) for the clinical outcomes of patients with acute pancreatitis. Methods Clinical data of AP patients who were admitted to The First Affiliated Hospital of Naval Medical University (Second Military Medical University) from Jan. 2020 to Jun. 2021 were retrospectively analyzed. PNV was measured manually using Philips-IntelliSpace Portal. Scoring systems (acute physiological and chronic health evaluation Ⅱ [APACHE Ⅱ］, modified Marshall, Ranson, bedside index for severity of acute pancreatitis[BISAP］, Balthazar, and computed tomography severity index[CTSI］scores) were calculated. Receiver operating characteristic (ROC) curves were used to compare the efficacy of PNV with different scoring systems and 48 h-CRP in predicting prognostic parameters such as organ dysfunction, multiple organ failure (MOF), length of hospital stay, intensive care unit (ICU) stay, and complications during hospitalization, infection and necrosis, and requirement of surgery or intervention. Results A total of 150 AP patients were included, and the PNV (ranged from 20.0 to 1 517.5[539.5±413.4］cm³) was measured manually. PNV was positively correlated with the length of hospital stay (correlation coefficient was 0.462, P＜0.05). The area under curve values (95% confidence interval[CI］) of PNV in predicting infection, complications, MOF, ICU admission, and organ dysfunction were 0.73 (0.60-0.85), 0.72 (0.77-0.88), 0.86 (0.76-0.97), 0.90 (0.82-0.98), and 0.88 (0.80-0.97), the sensitivities were 0.72, 0.67, 0.67, 0.63, and 0.81, and the specificities were 0.99, 0.98, 0.75, 0.81, and 0.91, respectively. The analyses of the ROC curves showed that PNV was the best parameter to predict the prognosis of AP compared with the scoring systems or 48 h-CRP. Conclusion PNV may be useful in predicting the severity of AP.

Abstract:Objective To explore the effects of spinal anesthesia (SA) and general anesthesia (GA) under the guidance of enhanced recovery after surgery (ERAS) concept on minimally invasive transforaminal lumbar interbody fusion (MIS-TLIF) through a retrospective cohort study. Methods Perioperative data of 40 patients who underwent MIS-TLIF in The Affiliated Hospital of Chengdu University from Jan. 2019 to Dec. 2021 were retrospectively analyzed, with 20 patients in the SA group and 20 in the GA group. The operative time, intraoperative adverse events, postoperative adverse events, postoperative hospital stay, numeric rating scale (NRS) pain score within 3 h in post-anesthesia care unit (PACU), opioid use, and the time from admission to the first mobilization of patients were collected, and the differences between the 2 groups were compared. Results There were no significant differences in the general data between the 2 groups (all P＞0.05). Compared with the GA group, patients receiving MIS-TLIF in the SA group had shorter total operating room time ([192.18±18.09］min vs[223.22±19.54］min, P＜0.001), shorter time to leave operating room ([5.44±1.95］min vs[9.94±1.28］min, P＜0.001), lower mean intraoperative heart rate ([67.39±7.44］min^-1 vs[72.94±8.61］min^-1, P=0.035), lower mean intraoperative arterial pressure ([78.38±9.88］mmHg vs[84.47±8.30］mmHg, P=0.041) (1 mmHg＝0.133 kPa), lower NRS pain score within 3 h in PACU ([3.81±1.87］points vs[5.43±2.24］points, P=0.017), lower dose of opioid analgesics (morphine sulfate) within 3 h in PACU ([5.36±1.71］mg vs[7.22±2.01］mg, P=0.003), later time of the first use of analgesics after operation ([58.11±20.19］min vs[45.58±17.16］min, P=0.041］, and earlier time from admission to the first mobilization [(430.77±122.38］min vs[843.86±95.44］min, P＜0.001］. There were no significant differences in total operation time, intraoperative blood loss, or postoperative hospital stay between the 2 groups (all P＞0.05). Conclusion AS can be used for MIS-TLIF operation under the guidance of ERAS concept, and it can effectively reduce the operating room time and postoperative pain, also with an earlier return to normal activities.

Abstract:Objective To explore the clinical effect of breast-conserving surgery on young patients with breast cancer. Methods A total of 208 young breast cancer patients (age≤35 years) who were admitted to The Second Affiliated Hospital of Nanchang University from Feb. 2012 to Feb. 2017 were enrolled and divided into breast-conserving group (n=64) and modified radical mastectomy group (control group, n=144). The Mann-Whitney U test was used to analyze the differences in the intraoperative blood loss, postoperative drainage, and hospital stay between the 2 groups. The Kaplan-Meier method was used to analyze the disease-free survival (DFS) of the 2 groups. Univariate and multivariate Cox proportional hazards regression models were used to analyze the effect of breast-conserving therapy on DFS of young breast cancer patients. Results The intraoperative blood loss and postoperative drainage of patients in the breast-conserving group were significantly less than those in the control group (both P＜0.05), and the hospital stay was significantly shorter than that in the control group (P＜0.05). The DFS of the breast-conserving group was significantly shorter than that of the control group (55.3 months vs 58.1 months, P=0.001). Multivariate Cox proportional hazards regression model analysis showed that breast-conserving therapy (hazard ratio [HR］＝3.090, 95% confidence interval[CI］1.498-6.371, P=0.002), histological grading of tumor (Ⅲ) (HR=4.572, 95% CI 1.055-19.813, P=0.042), and triple negative breast cancer (HR=4.302, 95% CI 1.142-16.212, P=0.031) were independent risk factors of DFS in young breast cancer patients. Conclusion Breast-conserving surgery has the advantages of less trauma and shorter hospital stay in young patients with breast cancer, but the prognosis of the breastconserving surgery is worse than that of the modified radical mastectomy. Therefore, young breast cancer patients have to make their choice carefully.

Abstract:Paraspeckles are important subnuclear bodies in the nucleus. They can regulate gene expression by holding RNA or protein and interacting with miRNA, thus playing important roles in the development and progression of cancers. Studying the biological structure and function of paraspeckles in cancer cell is crucial for the diagnosis and treatment of cancers; however, the structure, function, and clinical significance of paraspeckles in cancer cell are still elusive. This paper reviews the composition, structure, and assembly of paraspeckles, and its mechanisms and clinical significance in the development and progression of cancers, so as to provide research directions and clues for the tumor diagnosis, treatment, and prognosis.

Abstract:Ferroptosis is an iron-dependent, non-apoptotic programmed cell death pattern. So far ferroptosis has been proved to be involved in the pathophysiological mechanisms of many diseases, such as neurodegenerative diseases, ischemia/ reperfusion injury, and tumors. Exosomes, as an intercellular messaging pathway, have been reported to play an important role in regulating ferroptosis process. Meanwhile, exosomes are increasingly used in diseases as a drug delivery vehicle due to low immunogenicity, good biocompatibility, and high efficiency. This article summarizes the regulatory role of exosomes in ferroptosis-related diseases and novel exosome therapeutic strategies targeting ferroptosis.

Abstract:As a stressor, social isolation in adolescence can lead to changes in social behavior and neuroendocrine system network function of animals and humans. A large number of studies have found that exposure to social isolation stress can induce specific changes in the function of different areas of the brain, active the hypothalamic-pituitary-adrenal axis, synthesize and release neurotransmitters such as dopamine, serotonin, γ-aminobutyric acid, and glutamate, and change the sensitivity of their receptors. These changes can induce different degrees of depressive-like behavior in animals and humans, which is closely related to the occurrence of depression. Adolescence is a critical period for neural networks, function and chemical reorganization of the brain, and compared with social isolation in adulthood, adolescent social isolation has a sustained and irreversible negative impact, greatly increasing the risk of mental illness in individuals. This article reviews the brain mechanisms associated with depression caused by social isolation in adolescence, discusses the specific effects of adolescent social isolation on brain development, endocrine, neurotransmitters, and glial cells, and discusses its association with depression.

Abstract:With the development of military weapons, abdominal injury caused by high-powered precision-guided bombs has become the most common injury in naval combat. Meanwhile, it often combines with seawater immersion injury in the naval combat environment, causing seawater-immersed opened abdominal injury. This paper analyzes the injury mechanism, characteristics, and treatment difficulties of seawater-immersed opened abdominal injury and proposes a “two-part, three-stage” damage-control surgical treatment strategy based on the concept of damage control surgery for this type of injury. The key points of each stage of the treatment, as well as the future application of this treatment strategy, are also introduced.

Abstract:Objective To explore the prescription rules of ancient physicians in the treatment of obese polycystic ovary syndrome (PCOS) by data mining, summarize the core prescriptions and drugs and explore the potential material basis and mechanism of core prescriptions using network pharmacology, so as to provide a reference for traditional Chinese medicine (TCM) treatment of obese PCOS. Methods Based on the Chinese Medical Code, a prescription database was established by Excel 2018. The ancient prescriptions of obese PCOS were analyzed by SPSS Modeler 18 and Gephi 0.9.7 software. Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform (TCMSP) was used to obtain the components and targets of the core prescriptions. The Human Gene Database (GeneCard) and Online Mendelian Inheritance in Man Database (OMIM) were used to obtain the disease targets, and then intersection genes of drug targets and disease targets were obtained. Cytoscape 3.7.1 software was used to construct the active components-intersection genes network, and Database for Annovation, Visualization, and Integrated Discovery (DAVID) was used for tissue enrichment analysis. Results A total of 47 prescriptions for obese PCOS were obtained, involving 98 kinds of TCMs. The TCMs with frequency ≥5 were Poria, Rhizoma Pinelliae, Radix Glycyrrhizae, Pericarpium Citri Reticulatae, Radix chuanxiong, Rhizoma Cyperi, Rhizoma Atractylodis macrocephalae, Radix Angelicae sinensis, Rhizoma Atractylodis, Rhizoma Arisaematis, Radix Ginseng, Talcum, Fructus Aurantii, Radix Paeoniae Alba, Rhizoma Coptidis, Radix Rehmanniae, Citri Exocarpium Rubrum, and Fructus Amomi. The core drug pair combination with strong correlation was Rhizoma Pinelliae, Pericarpium Citri Reticulatae, Poria, and Radix Glycyrrhizae (Erchen decoction). A total of 125 components and 218 target genes were obtained from TCMSP database; 2 962 disease target genes were obtained from GeneCard and OMIM, and 149 intersection genes of obese PCOS target genes and core drug target genes were obtained. Network pharmacology showed the active ingredients of the drugs with high degree values included quercetin, kaempferol, and formononetin, and the target genes with high degree values included prostaglandin endoperoxide synthase 2, estrogen receptor 1, and androgen receptor. The tissue enrichment analysis showed that the intersection target genes were mainly enriched in the placenta, liver, lung, and epithelium. Conclusion The data mining results suggest that the main principle of treating obese PCOS is to dry dampness, remove phlegm, benefit Qi, and strengthen spleen, while supplemented with drugs that nourish blood and regulate menstruation. The network pharmacology results have verified the results of ancient literature analysis, suggesting that flavonoids may improve obese PCOS by modulating hormone receptors.

Abstract:Objective To analyze the prescription rules of Pheretima in the Dictionary of Traditional Chinese Medicine Prescriptions based on the Traditional Chinese Medicine Inheritance Support System (TCMISS), so as to provide a theoretical basis for the modern clinical application and new drug development of Pheretima. Methods The prescriptions containing Pheretima were collected from the Dictionary of Traditional Chinese Medicine Prescriptions and input into TCMISS (V2.5) to establish a database. The frequencies of compatibility medicinal materials, meridian of drug, and attending diseases were analyzed statistically. The association rules of the software and improved mutual information method were used to analyze the core drug combinations. “Bi syndrome” and “traumatic injury” with higher compatibility frequencies were selected and analyzed in respect of the prescription rules, core drug combinations, and new prescription combinations. Results A total of 281 prescriptions, 287 commonly used drugs, and 29 commonly used drug combinations (frequencies≥20) were screened. The frequencies of 4 natures of compatible drugs were mainly warm and cold (73.5% of the total frequency). The frequency of pungent was the highest in 5 flavors, followed by bitter, sweet, and salty (these 4 accounted for 95.9% of the total frequency). The meridian frequencies of the liver, spleen, heart, stomach, bladder, kidney, and lung ranked the top 7 (frequencies≥400), accounting for 91.8% of the total frequency. A total of 103 kinds of diseases were treated with prescriptions containing Pheretima, involving 18 kinds of attending diseases (frequencies≥6). The core drug combinations (support level 20%) was Aconiti Radix Cocta, Olibanum, Myrrha, Angelicae Sinensis Radix, and Moschus. The prescription rules of “Bi syndrome” and “traumatic injury” were analyzed, 15 groups of drugs were obtained for the treatment of “Bi syndrome” (confidence 1), and the core drug combinations (support level 31.8%) were Aconiti Radix Cocta, Aconiti Kusnezoffii Radix Cocta, Olibanum, Myrrha, Clematidis Radix Et Rhizoma, and Faecas Trogopterori; 20 groups of drugs were obtained for the treatment of “traumatic injury” (confidence 0.9), and the core drug combinations (support level 31.5%) were Aconiti Radix Cocta, Olibanum, Myrrha, Pyritum, Sappan Lignum, Angelicae Sinensis Radix, and Draconis Sanguis. Conclusion Pheretima in the Dictionary of Traditional Chinese Medicine Prescriptions is mostly compatible with drugs of promoting blood circulation and removing blood stasis, and dispelling wind and dampness. The prescription and medication method are clear. It can scientifically and intuitively reflect the prescription rules of Pheretima by analyzing the Pheretima prescriptions with TCMISS. The core drugs obtained by analyzing the attending diseases can reflect the basic treatment of the diseases, and it is in line with the clinical practice. The core drug combinations can also provide references for clinical application and new drug development.

Abstract:Objective To investigate the clinical and lung imaging features of patients with myeloperoxidase (MPO)- positive antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) with lung involvement. Methods The general data, laboratory examinations, lung imaging changes, and complications of 59 patients with MPO-ANCA positive and diagnosed as AAV in the Department of Nephrology of No. 960 Hospital of Joint Logistics Support Force of PLA from Jan. 2014 to Dec. 2020 were retrospectively analyzed. According to the results of urine routine, serum creatinine, and estimated glomerular filtration rate, the patients were divided into simple lung injury group and lung and kidney combined injury group, and the above data of the 2 groups were compared and analyzed. Results Among the 59 patients, there were 27 males and 32 females, with an onset age of 24-93 (61.8±15.6) years old. There were 13 patients in the simple lung injury group and 46 in the lung and kidney combined injury group. There were no significant differences in age or gender of onset between the 2 groups (both P＞0.05). Compared with the simple lung injury group, the levels of hemoglobin ([85.13±23.79］g/L vs[116.38±23.99］g/L), albumin ([27.55±4.68］g/L vs[34.75±5.31］g/L), and the proportion of weight loss (4.3% [2/46］vs 30.8%[4/13］) in the lung and kidney combined injury group were significantly decreased, while the erythrocyte sedimentation rate ([73.60±35.04］mm/1 h vs[57.77±34.56］mm/1 h), C reactive protein (28.15[5.08, 103.00］mg/L vs 14.30[5.55, 58.70］mg/L), and the proportions of nausea/fatigue (37.0%[17/46］vs 7.7%[1/13］) and hypertension (87.0%[40/46］ vs 46.2%[6/13］) were significantly increased (all P＜0.05). All the 59 patients underwent chest computed tomography, and the most common imaging changes were grid changes, patch consolidation, and pleural thickening, but these characteristic changes had no significant differences between the 2 groups (all P＞0.05). Conclusion The lung imaging changes in MPOANCA positive AAV patients are varied, but the changes in the 2 groups are not specific. The lung and kidney combined injury group have more patients with hypertension and are prone to developing severe anemia and hypoproteinemia, suggesting a poor prognosis.

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