Abstract:The incidence and mortality of colorectal cancer in China are increasing year by year, and it could be effectively curbed by early prevention, screening, diagnosis and treatment. Colonoscopy is one of the most important means to screen and detect colorectal cancer. The adenoma detection rate is a key quality control index for colonoscopy. Improving the adenoma detection rate can not only improve the quality of colonoscopy, but also significantly reduce the incidence and mortality of colorectal cancer, which is of great clinical significance. Our team explores several ways to improve the adenoma detection rate from different levels such as bowel preparation quality, operation skills of entering endoscopy, time and quality of exiting endoscopy, and artificial intelligence system, so as to lay a solid foundation for endoscopists at the colonoscopy learning stage, effectively improving the low adenoma detection rate during colonoscopy in our country.

Abstract:Objective To discuss the disease spectrum and pathological characteristics of retroperitoneal tumors. Methods The pathological information of 1 050 patients who were diagnosed with "retroperitoneal mass/tumor" by the surgical team led by Dr. FENG Xiang of The First Affiliated Hospital of Naval Medical University (Second Military Medical University) from Jan. 2012 to Dec. 2021 was retrospectively collected, and the proportions of various types of tumors were analyzed, as well as the clinical and pathological features. Results A total of 1 050 pathological specimens were included:407 (38.76%) tumors of mesenchymal origin, including 348 (33.14%) malignant tumors and 59 (5.62%) benign tumors; 211 (20.10%) tumors of neurogenic origin, including 18 (1.71%) malignant tumors and 193 (18.38%) benign tumors; 127 (12.10%) tumors of lymphohematopoietic origin, including 88 (8.38%) malignant tumors and 39 (3.71%) benign tumors; 19 (1.81%) other primary retroperitoneal tumors; 42 (4.00%) malignant tumors of unknown origin; and 244 (23.24%) metastatic tumors. Among the malignant tumors of mesenchymal origin, the most common pathological types were liposarcoma (178 cases, 16.95%), and leiomyosarcoma (54 cases, 5.14%). Conclusion Among retroperitoneal tumors, mesenchymal tumors are the most common, followed by neurogenic tumors, lymphoid hematopoietic tumors and metastatic tumors.

Abstract:Objective To explore the characteristics of sagittal spino-pelvic parameters in patients with chronic low back pain and their relationship with chronic low back pain. Methods From Jul. 2019 to Jun. 2021, 249 patients with chronic low back pain (LBP group) and 86 physical examination adults without low back pain symptoms (control group) were selected as subjects in The First Affiliated Hospital of Naval Medical University (Second Military Medical University). The general data of the 2 groups were collected, the thoracic kyphosis (TK), lumbar lordosis (LL), LL-TK, sacral inclination (SS), pelvic inclination (PT), pelvic incidence (PI), SS-PT, LL-PI, sagittal verticalaxis (SVA) and other sagittal parameters were measured on the full-length anteroposterior and lateral X-ray films of the spine, and the differences between the 2 groups were observed. Results There were no significant differences in age, gender or body mass index between the 2 groups (all P>0.05). TK in the LBP group was higher than that in the control group, while LL-TK, SS, PI and SS-PT in the LBP group were lower than those in the control group (all P<0.05). There were no significant differences in LL, PT, LL-PI or SVA between the 2 groups (all P>0.05). The types of lordosis were mainly type 2 (SS<35°, small LL, the apex of lumbar lordosis is located in L₄) in the LBP group and control group, accounting for 70.7% (176/249) and 57.0% (49/86), respectively. There was no significant difference in the composition ratio of lordosis types between the 2 groups (χ²=6.161, P=0.104). Conclusion The sagittal spino-pelvis parameters of patients with chronic low back pain are different from those of adults without low back pain symptoms. Large TK, small SS, and small PI are more common in the low back pain patients, suggesting that this particular pattern is related to chronic low back pain.

Abstract:Objective To explore whether c-Jun N-terminal kinase (JNK) pathway is involved in the osteogenic differentiation of human periodontal ligament stem cells (hPDLSCs) induced by low-frequency pulsed electromagnetic field (PEMF) via using the specific inhibitor SP600125 to intervene JNK signaling pathway. Methods hPDLSCs were exposed to the low-frequency PEMF stimulation (15 Hz, 0-3.0 mT, radiate for 1 h every 12 h) in vitro for 7 d or 14 d and the expression levels of osteogenic-related genes Runt-related transcription factor 2 (Runx2), alkaline phosphatase (ALP), osteopontin (OPN) and osteocalcin (OCN) were detected by quantitative polymerase chain reaction (qPCR), so as to determine the osteogenic differentiation ability of cells induced by low-frequency PEMF and the appropriate magnetic field intensity. To determine whether JNK pathway plays a role in the osteogenic differentiation of hPDLSCs stimulated by low-frequency PEMF, the expression levels of JNK and phosphorylated-JNK (p-JNK) proteins were detected by Western blotting; and the expression levels of osteogenic genes in cells treated with different concentrations of SP600125 were detected by qPCR. Results The expression levels of osteogenic-related genes Runx2, ALP, OPN and OCN were higher in hPDLSCs irradiated with low-frequency PEMF at 15 Hz and 2.5 mT than other intensity groups (all P<0.05). Low-frequency PEMF significantly stimulated the expression of JNK and p-JNK proteins in cells (both P<0.05). The expression levels of osteogenic genes in hPDLSCs were decreased after the JNK pathway was inhibited by SP600125, and the inhibitory effects of 20 and 30 μmol/L SP600125 were more obvious than that of 10 μmol/L SP600125 (both P<0.05). Conclusion PEMF (15 Hz,2.5 mT) partially activates JNK pathway to induce hPDLSC osteogenic differentiation.

Abstract:Objective To prepare an interfering adenovirus targeting zinc finger and BTB domain containing 20 (ZBTB20) gene. Methods The human and mouse interference primers were designed based on the ZBTB20 gene sequence, and cloned into BamH Ⅰ and Hind Ⅲ restriction endonuclease sites of the adenovirus shuttle vector pShuttle-U6-GFP. The shuttle plasmid pShuttle-shZBTB20 was linearized by Pme Ⅰ and then transformed into pAdEasy-1/BJ5183 bacterial cells for generating homologous recombinant adenovirus plasmid pAd-shZBTB20. The recombinant adenovirus plasmid was linearized with Pac Ⅰ and transfected into HEK-293 packaging cells. The titer of virus was measured by tissue culture infectious dose 50 (TCID₅₀) assay. The interference efficiency of endogenous ZBTB20 gene was detected in Huh7 cells and liver tissue in the mice. Results The adenovirus vector targeting human and mouse ZBTB20 gene was successfully constructed, and the highly active ZBTB20 interfering adenovirus Ad-shZBTB20 was obtained, with the titer of 3.2×10¹⁰ IU/mL. The expression of endogenous ZBTB20 mRNA was significantly reduced to 20% of the control in human hepatoma cell line Huh7 infected with the interfering adenovirus for 96 h. After 7 d of tail vein injection (1×10¹⁰ VG/mouse), ZBTB20 protein was dramatically down-regulated in the liver, and its downstream target gene α-fetoprotein mRNA level was increased by 203 times. Conclusion The prepared ZBTB20-interfering adenovirus can effectively inhibit the expression of human and mouse ZBTB20 and its biological effects.

Abstract:Objective To observe the effect of Astragalus polysaccharides on the Ca²⁺ regulatory indexes of polyamine signaling pathway during the migration of rat intestinal epithelial cell line IEC-6 cells, so as to explore the mechanism by which Astragalus membranaceus promoting the repair of gastrointestinal mucosal injury. Methods The cell migration model was established by scratch method and the effect of Astragalus polysaccharide on cell migration was observed in calcium-free culture. The expression of transient receptor potential channel 1 (TRPC1), stromal interaction molecule (STIM)1 and STIM2 mRNA was determined by quantitative polymerase chain reaction. The distribution and expression of STIM1 protein were detected by immunofluorescence. The expression of TRPC1, STIM1 and STIM2 was detected by Western blotting. The expression of STIM1/TRPC1 and STIM1/STIM2 complexes was detected by immunoprecipitation. Results The promoting effect of Astragalus polysaccharides on cell migration was attenuated in calcium-free culture (removing the source of extracellular Ca²⁺ influx) (P<0.01). Astragalus polysaccharides had promoting effects on TRPC1 mRNA and protein expression (P<0.05 or P<0.01), and had reversal effects on TRPC1 mRNA and protein expression in difluoromethylornithine (DFMO) treated cells (P<0.01). Astragalus polysaccharide promoted the translocation of STIM1 to the plasma membrane and increased STIM1 protein expression, and reversed the translocation of STIM1 to the plasma membrane and the inhibition effect which was found in DFMO-treated cells. Astragalus polysaccharides increased the expression of STIM1 mRNA and protein and reversed the inhibition effects on STIM1 mRNA and protein expression induced by DFMO (P<0.05 or P<0.01). In addition, Astragalus polysaccharides reduced the expression of STIM2 mRNA and protein and reversed the increased expression of STIM2 mRNA and protein induced by DFMO (P<0.05 or P<0.01). Astragalus polysaccharides increased the expression of STIM1/TRPC1 complex and reversed the inhibition effect of DFMO on STIM1/TRPC1 complex expression, modulated the expression of STIM1/STIM2 by increasing STIM1 expression and reducing STIM2 expression, and antagonized the effect of DFMO on STIM1/STIM2 expression. Conclusion The role of Astragalus polysaccharides in promoting the migration of IEC-6 cells is related to its effect on the expression of Ca²⁺ regulatory protein and protein complex.

Abstract:Objective To investigate the role of S100 calcium binding protein A11 (S100A11) in aortic dissection (AD) and its possible mechanism. Methods In vivo, lentivirus plasmid Lv-S100A11-shRNA and negative control plasmid Lv-NC-shRNA were constructed and transfected into HEK293T cells respectively to obtain viral supernatant. Forty SD rats were randomly divided into 5 groups:control group (without any intervention), sham operation group (with physiological saline injected into the tail vein), AD group (with 0.25% β-aminopropionitrile added into drinking water for 3 consecutive weeks to establish AD model), AD+Lv-NC-shRNA group (AD model rats were injected with Lv-NC-shRNA via tail vein) and AD+Lv-S100A11-shRNA group (AD model rats were injected with Lv-S100A11-shRNA via tail vein), with 8 rats in each group. Hematoxylin-eosin (H-E) staining was used to observe the histopathological changes of the aorta, terminal deoxynucleotidyl transferase-mediated dUTP-biotin nick end labeling (TUNEL) staining was used to observe cell apoptosis, immunohistochemistry staining was used to detect the protein expression levels of S100A11 and downstream signaling pathway related proteins receptor for advanced glycation endproducts (RAGE) and phosphorylated p38 (p-p38), and Western blotting was used to detect the protein expression levels of migration proteins matrix metalloproteinase (MMP) 2 and MMP9, apoptosis proteins B-cell lymphoma-2 (Bcl-2) and Bcl-2-associated X (Bax), proliferation proteins proliferating cell nuclear antigen (PCNA) and Ki-67. In vitro, the S100A11 overexpression plasmid OV-S100A11 was constructed, and human aortic smooth muscle cells (HASMC) were divided into 3 groups:control group (without any intervention), EV group (transfected with pIRES2-GFP empty vector) and OV-S100A11 group (transfected with pIRES2-GFP-S100A11 overexpression S100A11). Flow cytometry was used to detect apoptosis, and then the cells transfected with pIRES2-GFP-S100A11 were treated with RAGE inhibitor FPS ZM1 and p38 phosphorylation inhibitor SB203580. Western blotting was used to detect the protein expression of S100A11, RAGE, p38, p-p38, MMP2, MMP9, Bax, Bcl-2, PCNA and Ki-67. Results The results of animal experiments showed that compared with the sham operation group, the aortic vessels of rats in the AD group formed a blood-filled dissection, the apoptotic cells were increased, the protein levels of S100A11, RAGE, p-p38, MMP2, MMP9 and Bax were increased (all P<0.01), while the protein levels of Bcl-2, PCNA and Ki-67 were decreased (all P<0.01). Compared with the AD group, the aortic lesions in the Lv-S100A11-shRNA group were relieved, the apoptotic cells were decreased, the levels of S100A11, RAGE, p-p38, MMP2, MMP9 and Bax were decreased (all P<0.01), while the protein levels of Bcl-2, PCNA and Ki-67 were increased (all P<0.01). The results of cell experiments showed that the apoptosis rate of OV-S100A11 group was increased compared with the control group (all P<0.01), the protein levels of RAGE, p-p38, MMP2, MMP9 and Bax in the cells were increased (all P<0.01), the protein levels of Bcl-2, PCNA and Ki-67 were decreased (all P<0.01), but the change of the above proteins was reversed after the treatment with FPS ZM1 and SB203580. Conclusion S100A11 is highly expressed in AD formation rats, and it can promote cell apoptosis through RAGE-p38 mitogen activated protein kinase pathway, participating in AD formation.

Abstract:Objective To explore the pre-exposure prophylaxis (PrEP) risk compensation of men who have sex with men (MSM) and the intervention of human immunodeficiency virus (HIV) self-testing on relevant risk behaviors in Chongqing. Methods Eligible MSM were recruited in Chongqing from Jun. 2018 to Jun. 2019. Truvada (Emtricitabine and Tenofovir Disoproxil Fumarate tablets) was prescribed as the PrEP drug of choice, and the subjects were randomly assigned at a ratio of 1:1 (by drawing lots) into HIV self-testing intervention group and control group. After 6 months of follow-up, the effect of HIV self-testing on PrEP risk compensation was investigated. Results A total of 126 subjects were included, and 93 eventually completed the study, including 43 in the HIV self-testing group and 50 in the control group. There was no significant increase in PrEP related risk behaviors during the follow-up period, but the number of participants who were engaged in receptive penetrative sex, the number of participants who had unprotected anal sex with partners having unknown HIV status, and the incident rate of new sexually transmitted diseases all showed an increasing trend. In addition, the proportions of subjects with condom use rate<50% in the HIV self-testing group were significantly higher than those in the control group (P=0.035, P=0.043) at the 3^rd and 6^th months of follow-up. Conclusion PrEP-related risk behaviors of MSM in Chongqing do not show a significant increase at 6 months of follow-up. However, some risk behaviors show an upward trend. MSM who use HIV self-testing may have risk compensation behaviors, which should be alerted and education should be strengthened.

Abstract:Objective To establish and verify a high-performance liquid chromatography (HPLC) method for determining the content and related substances of a prefilled syringe lidocaine hydrochloride injection, and to carry out the stability study with this method. Methods Referring to the 2020 Chinese Pharmacopoeia, HPLC method was used to determine the drug content and related substances. The content of the drug was determined by Agilent Eclipse XDB-C₁₈ column (4.6 mm×250 mm, 5 μm), the mobile phase was acetonitrile phosphate buffer (60:40, volume ratio), the flow rate was 1.0 mL/min, the injection volume was 20 μL, and the detection wavelength was 254 nm. For the determination of drug-related substances, the chromatographic conditions were consistent with the determination of drug content, except that the mobile phase was acetonitrile-phosphate buffered saline (50:50, volume ratio) and the detection wavelength was 230 nm. With the above HPLC method, the drug content and related substances in the prefilled syringe lidocaine hydrochloride injection were determined, and the injection stability was also studied. Results The linearity of the method was good in the range of 80.00-300.00 μg/mL (y=0.034 3x+0.162 7, r=0.999 9), with a mean recovery of 101.38% (relative standard deviation=0.39%, n=9). 2,6-dimethylaniline, the related substances of lidocaine hydrochloride, could be well separated from lidocaine hydrochloride during the chromatographic separation. The resolution was greater than 1.5. The blank excipients did not interfere with the determination, and the stability was good. Conclusion The established method can be used for the determination of the content and related substances of the prefilled syringe lidocaine hydrochloride injection. It is simple, accurate, sensitive and specific, and provides a quantitative analysis method for the quality study of the prefilled syringe lidocaine hydrochloride injection. The preparation quality is stable and reliable under different conditions.

Abstract:Objective To compare the clinical diagnostic value of 2 different cardiac contrast-enhanced ultrasound (CEUS) techniques (ultrasonic microbubble angiography and rapid turbulence angiography) in determining the position of the central venous catheter tip. Methods A total of 107 adult critical patients with central venous catheterization who were admitted to Department of Critical Care Medicine, Peking University People's Hospital from Jul. 2020 to Mar. 2022 were enrolled. The position of the central venous catheter tip was determined by ultrasonic microbubble angiography and rapid turbulence angiography. The accuracy of the 2 CEUS techniques in determining the position of the central venous catheter tip was analyzed using the results of bedside chest X-ray (CXR) as the standard. Results The median time required to determine the position of the central venous catheter tip by ultrasonic microbubble angiography and rapid turbulence angiography was 6 (5-7) min and 5 (4-6) min, respectively, which were shorter than that by bedside CXR (70[57-90] min) (both P<0.01). With bedside CXR as the gold standard for the determination of catheter position, the ultrasonic microbubble angiography and rapid turbulence angiography showed consistent results, with a sensitivity of 100.0% and a specificity of 81.2% for both methods. Conclusion Compared with bedside CXR, the ultrasonic microbubble angiography and rapid turbulence angiography can determine the position of the central venous catheter quickly and accurately. In addition, rapid turbulence angiography without injection of contrast agent is more worthy of further clinical application.

Abstract:In recent years, with the development and maturation of minimally invasive techniques, laparoscopic and robotic surgery has been increasingly used in clinical practice, and several authoritative guidelines recommend minimally invasive surgery as a standard surgical approach for early-stage endometrial cancer. Several previous randomized controlled trials have confirmed the effectiveness and safety of laparoscopic surgery, but the results of the Laparoscopic Approach to Cervical Cancer Trial showed that the overall survival rate of patients with early-stage cervical cancer was lower than that of open surgery, which has triggered extensive controversies on the safety of laparoscopic surgery. Therefore, this article reviews a large amount of domestic and international literatures and presents a review of the research progress and safety of laparoscopic surgery for endometrial cancer, intending to provide a reference for clinical and scientific work.

Abstract:Atrial fibrillation (AF), one of the most common arrhythmias, accounts greatly for the morbidity and mortality of cardiovascular diseases. Epicardial adipose tissue (EAT), a kind of special adipose tissue, is anatomically located between the visceral pericardium and myocardium. EAT is involved in the development and maintenance of AF, but the mechanisms have not been fully elaborated. EAT-derived extracellular vehicles (EVs) have gained much attention recently. This paper mainly reviews the characteristics and quantitative detections of EAT, especially the role of EVs in the development of AF and its relationship with myocardial structural and electrical remodeling, so as to provide new insights on the pathogenesis of AF and reference for the treatment of AF in the future.

Abstract:Drowning is an important public health safety issue and is one of the most common causes of accidental death. Lungs are one of the main organs damaged after drowning. Inhalation of seawater or freshwater will directly damage lung tissue, and induce oxidative stress and inflammatory responses to further aggravate lung damage. Nearly 1/3 of patients eventually progress to acute respiratory distress syndrome. The combined effect of pathological changes such as alveolar surfactant disruption, altered alveolar epithelial structure and function and increased pulmonary capillary permeability ultimately leads to decreased lung compliance, increased intrapulmonary shunt, atelectasis and pulmonary edema. However, because seawater is a hypothermic and hypertonic liquid and contains a large number of bacteria, it produces more intense damaging stimulation in the lungs and alveoli. Therefore, the course of acute respiratory distress syndrome induced by seawater drowning is more rapid and the mechanism is more complex. This article reviews the research progress on the mechanism of seawater drowning-induced lung injury in order to provide new ideas for its treatment.

Abstract:The combat of warship fleet in far-sea environment will become the main form of combat of our navy. The battlefield of far-sea combat is vast, the attack and defense situation changes quickly, and the wound condition is complex. It is easy to produce a large number of wounded at any time and at any location, making it very difficult to rescue and treat. This paper systematically introduces a new type of advanced trauma surgical mobile rescue team for far-sea fleet combat and its exclusive modular, standardized and lightweight surgical resuscitation equipment system, and explains the concept of the training system for health service researchers and participants.

Abstract:Objective To investigate the advantages and disadvantages of retrograde arterial approach and transatrial septal approach for radiofrequency ablation of left-sided accessory pathways, and to evaluate the performance of a domestic three-dimensional (3D) cardiac electrophysiological mapping system. Methods From Jul. 2019 to Aug. 2020, 30 patients with supraventricular tachycardia were enrolled in this prospective, randomized controlled study. The left-sided accessory pathways were determined by cardiac electrophysiological examination before operation and all the patients had the indications for catheter radiofrequency ablation. The patients were randomly assigned to retrograde arterial approach group and transatrial septal approach group at a ratio of 1:1. Under the guidance of a domestic 3D cardiac electrophysiological mapping system (Columbus^® system), radiofrequency ablation of left-sided accessory pathways was performed, and the success rate of target mapping, success rate of immediate postoperative ablation, X-ray exposure duration, X-ray radiation dose, operation time and intraoperative and postoperative adverse events were compared between the 2 groups. Results The success rates of target mapping and immediate postoperative ablation were 100% in both groups. The procedure duration ([75.40±22.27] min vs[83.80±39.96]min), X-ray exposure time (384[310, 510]s vs 369[340, 989]s) or X-ray radiation dose (93[63, 123]mGy vs 154[56, 184]mGy) were not significantly different from those of the retrograde arterial approach group (all P>0.05). The incidence of postoperative adverse events was 6.7% (1/15) in the retrograde arterial approach group, and no adverse events occurred in the transatrial septal approach group (P>0.05). The domestic 3D cardiac electrophysiological mapping system could clearly visualize the catheter electrodes. The catheter had good operation performance, could be positioned smoothly, and the attachment was satisfactory. Conclusion The domestic 3D cardiac electrophysiological mapping system can be safely and effectively used for radiofrequency ablation of left-sided accessory pathway ablation. There are no differences in the procedure duration, X-ray exposure time, X-ray radiation dose or incidence of adverse events between transatrial septal approach and retrograde arterial approach.

Abstract:Objective To evaluate the efficacy and safety of toripalimab combined with sunitinib in the treatment of advanced renal cell carcinoma (RCC). Methods The clinical data of 25 patients with advanced RCC treated with toripalimab 240 mg by intravenous infusion every 3 weeks and sunitinib 50 mg orally once daily (with dose modifications according to patient tolerance) at The Second Affiliated Hospital of Naval Medical University (Second Military Medical University) from Jan. 2020 to Mar. 2022 were collected. The treatment effect was evaluated by imaging results, the efficacy was judged according to Response Evaluation Criteria in Solid Tumors (RECIST version 1.1), and adverse events were recorded according to Common Terminology Criteria for Adverse Events (CTCAE version 5.0). Survival analysis was performed by Kaplan-Merier method. Results Of the 25 patients, 21 were male and 4 were female, with a median age of 59 (95% confidence interval[CI]33-80) years old. The pathological types included clear cell renal cell carcinoma (ccRCC) in 23 patients, transcription factor 3 (TFE3) gene fusion-associated RCC in 2 patients, and ccRCC with partial sarcomatoid degeneration in 1 patient. All patients had local progression or distant metastasis, with a median follow-up of 11.0 (95% CI 2.5-24.0) months. All 25 patients were evaluable for efficacy, including partial response in 9 cases, stable disease in 12 cases, and progressive disease in 4 cases. The objective response rate was 36.0% (9/25), the disease control rate was 84.0% (21/25), the median progression-free survival was 12.7 (95% CI 10.7-14.7) months, and the median overall survival has not been reached yet. The overall incidence of adverse events was 88.0% (22/25). Common adverse events included rash, diarrhea, hand-foot skin reaction and hypertension, with 90.0% (45/50) of them being grade 1-2. Conclusion Toripalimab combined with sunitinib is efficient in the treatment of advanced RCC, and the safety events are generally manageable.

Abstract:Objective To explore the feasibility, safety and effectiveness of ultrasound-guided microwave ablation for benign parotid gland tumors. Methods From Jul. 2013 to Jun. 2021, ultrasound-guided core needle biopsy was performed on patients with clinically diagnosed parotid mass and suspected parotid tumor diagnosed by ultrasound. Benign parotid tumors based on the biopsy histopathology were treated by using ultrasound-guided microwave ablation. The ablated area of parotid gland was evaluated by dynamic ultrasound imaging, and complications related to needle biopsy and ablative treatment were followed up. Results A total of 13 parotid tumors underwent core needle biopsy as designed during the past 8 years. Twelve benign tumors were treated with ultrasound-guided microwave ablation, including 6 adenolymphomas, 4 polymorphic adenomas, 1 dermoid cyst, and 1 nodular lymphoid hyperplasia. The age of the 12 patients were 10-79 years old (median 60.5 years old), and the maximum diameter of the tumor was 17.8-49.0 mm (median 26.15 mm). Microwave ablation was performed all at one time with a duration of 70-598 s (median 155 s) in all patients. By the deadline of this paper, 10 patients had recovered, and the time required for complete absorption in the ablation area was 8-37 months (median 23.5 months). No residual tumor was observed in the ablation area and no neoplasm was observed in the rest parotid gland. There were no serious complications after ablation. Conclusion Ultrasound-guided microwave ablation can provide accurate and minimally invasive treatment opportunities for benign parotid tumors with mild complications.

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