Abstract:China is one of the countries with the highest incidence and mortality of esophageal cancer worldwide. Screening and early detection are the keys to relieve the disease burden. Upper gastrointestinal endoscopy is currently the gold standard for the diagnosis of esophageal cancer, but its invasiveness limits the applicability in mass screening. Developing readily accessible and efficient methods for risk stratification and referring high-risk individuals for endoscopy are more cost-effective and suitable for the condition of China. We reviewed new approaches and methods in esophageal cancer screening, including risk prediction model, esophageal cytology, and biomarkers of blood, exhaled air and saliva, and proposed the research prospect.

Abstract:Objective To induce human gallbladder epithelial cells (hGBECs) differentiating into hepatocyte-like cells through adding small molecule compounds which could change cell fate. Methods The primary hGBECs were three-dimensionally cultured in Matrigel by adding B27 supplement, N2 supplement, N-acetyl-L-cysteine, epidermal growth factor and hepatocyte growth factor in the medium. Small molecule compounds/proteins were added to induce cell differentiation, and the key molecules were screened out. Polymerase chain reaction (PCR), quantitative PCR, and immunofluorescence staining were used to detect the expression of stem cell markers and liver cell related markers. The liver function was evaluated by lipid BODIPY-493 staining, glycogen periodic acid-Schiff staining, and albumin enzyme-linked immunosorbent assay. Results Three-dimensionally cultured hGBECs expressed hepatic stem/progenitor cells-related markers, such as hematopoietic stem cell antigen CD133, epithelial cell adhesion molecule, and hepatocyte nuclear factor 4α. Transforming growth factor β (TGF-β) and Notch signaling pathway inhibitors were the key molecules for inducing hGBEC differentiation. The cells obtained under differentiation conditions expressed liver cell functional markers α1-antitrypsin, cytochrome P450 3A4, albumin and fumarate acetate hydrolase. The cells could store glycogen, synthesize fat and secrete albumin. Conclusion hGBECs can be cultured in vitro for a long time, and hGBECs can be induced to differentiate into hepatocyte-like cells with partial liver function by inhibiting TGF-β and Notch signaling pathways.

Abstract:Objective To establish a magnetic separation method for rapid and efficient culture of the primary C57BL/6J mouse ophthalmic artery smooth muscle cells (OASMCs). Methods High purity OASMCs were cultured and identified by combining tissue block adhesion method and enzyme digestion method and optimizing the key experimental steps, including collagenase, the formula of agarose iron powder (Ⅱ,Ⅲ) and particle size of iron powder. The specific procedures were as follows: under sterile conditions, the left ventricle of mouse was successively injected with 4 ℃ phosphate buffered saline and agarose iron powder suspension, and the ophthalmic artery was isolated under dissecting microscope. It was cut into tissue blocks of 1.0-1.5 mm, digested with collagenase for 45 min, then separated from the collagenase by magnetic separator, planted evenly in a petri dish, and incubated at 37 ℃ in an atmosphere of 5% CO₂ in air. The OASMCs were subcultured when they reached 85%-90% confluence. The cells from 3 to 7 generations were identified by morphology and immunofluorescence staining. Results The optimal experimental conditions were determined by changing different conditions: the ratio of collagenase to M199 medium was 0.001 5 g∶6 mL, the collagenase digestion time was 45 min, the particle size of iron powder was 5 μm, and the mass ratio of agarose to iron powder was 0.05 g∶0.05 g; the temperature of the agarose iron powder suspension was 37 ℃, and the injector model was 0.6 mm×25 mm TWLB. After 2 d in primary culture, there were long spindle cells crawling out from the tissue blocks of the ophthalmic artery, with a radioactive distribution. After 7 d, iron powder was gradually reduced by replacing new medium, the speed of cell confluence was accelerated, and the cells showed a typical long spindle-shape morphology. Immunofluorescence staining of the cultured OASMCs demonstrated positive α-smooth muscle actin. Conclusion The present method is rapid, efficient, and can achieve high purity cells for culturing primary C57BL/6J mouse OASMCs, which lays a foundation for screening drug activity of ophthalmic artery related diseases.

Abstract:Objective To investigate the impact of preoperative body mass index (BMI) on the survival and prognosis of patients with hepatocellular carcinoma (HCC) complicated with type 2 diabetes mellitus after radical resection. Methods The clinical data of 140 HCC patients with type 2 diabetes mellitus who underwent radical resection in The Third Affiliated Hospital of Naval Medical University (Second Military Medical University) from Jan. 2013 to Dec. 2014 were retrospectively analyzed. These patients were divided into 2 groups based on preoperative BMI (ranged 18.8-31.8 kg/m²): normal-BMI (18.8-24.9 kg/m²) group and high-BMI (25.0-31.8 kg/m²) group. The basic clinical data and prognostic factors of the 2 groups of patients were summarized and analyzed. Results Among the 140 patients, 94 (67.1%) and 46 (32.9%) were in the normal-BMI and high-BMI groups, respectively. There was no significant difference between the 2 groups in age, gender, laboratory examination indicators, pathological parameters, antiviral treatment, diabetes treatment, or postoperative preventive transcatheter arterial chemoembolization (all P＞0.05). The 3-year overall survival rate of the high-BMI group (86.0%) was higher than that of the normal-BMI group (64.8%), and there was a significant difference in the overall survival between the 2 groups (P＝0.011). Multivariate Cox proportional hazard regression analysis showed that high-BMI was an independent protective factor for the overall survival of HCC patients with type 2 diabetes after radical resection (hazard ratio＝0.379, 95% confidence interval 0.156-0.917, P＝0.031). Conclusion HCC patients complicated with type 2 diabetes mellitus with high preoperative BMI have significantly better overall survival.

Abstract:Objective To construct a prognostic prediction model for malignant tumor patients with sepsis-induced acute kidney injury (AKI) treated with continuous renal replacement therapy (CRRT) based on coagulation and inflammatory indicators. Methods Seventy-nine malignant tumor patients with sepsis-induced AKI treated with CRRT in our hospital from Jan. 2020 to Dec. 2021 were enrolled. They were divided into death group (n＝20) and survival group (n＝59) based on their prognosis within 28 d after CRRT. The baseline data and levels of coagulation and inflammation indicators were compared between the 2 groups before, 6 h and 12 h after CRRT, and variables with significant differences were included in the logistic regression analysis to identify risk factors that affect the prognosis of malignant tumor patients with sepsis-induced AKI. Results Compared with pre-treatment, the levels of platelet, D-dimer, fibrinogen, white blood cell, neutrophil ratio, C reactive protein (CRP), procalcitonin (PCT), interleukin (IL)-6 and IL-8 were significantly decreased at 6 h and 12 h after CRRT, while the prothrombin time, activated partial thromboplastin time and international normalized ratio were significantly increased (all P＜0.05). Diabetes mellitus, hypertension, metastasis and levels of platelet, D-dimer, CRP and PCT at 12 h after CRRT were independent risk factors for the death of malignant tumor patients with sepsis-induced AKI within 28 d (all P＜0.05). Logistic regression indicated that the prognosis prediction formula could be expressed by Y-union＝D-dimer＋2.134×platelet＋ 3.451×CRP＋4.160×PCT, and the threshold value＞293.124 indicated a higher risk of death within 28 d. Conclusion Levels of D-dimer, platelet, CRP and PCT in malignant tumor patients with sepsis-induced AKI at 12 h after CRRT can be used to predict the prognosis within 28 d.

Abstract:Objective To assess the value of the whole spine scanography with supine position under traction and the whole spine scanography with erect position in guiding the preoperative surgical plan for patients with moderate to severe scoliosis by comparing and analyzing the data of the 2 methods. Methods Patients with moderate to severe scoliosis who visited The Second Affiliated Hospital of Naval Medical University (Second Military Medical University) from Jan. to Dec. 2021 and had weight-bearing supine whole spine positive and lateral radiographs under traction were retrospectively selected, and a total of 82 patients were included after screening by inclusion criteria. The patients’ age, gender, preoperative erect position, weight-bearing supine position under traction and postoperative erect position whole spine Cobb angles, surgical options, postoperative Cobb angle correction rate and spinal flexibility were analyzed. The patients were divided into groups with spinal flexibility≥30% and spinal flexibility＜30%, and the relationships between spinal flexibility and postoperative correction rate, as well as the selection of orthopedic surgery options, were analyzed. Results Among the 82 patients, 57 were female and 25 were male, aged from 6 to 63 years, with an average age of (23.0±14.3) years. The preoperative Cobb angle was (69.90±27.74)°, the Cobb angle was (42.33±30.31)°under traction, postoperative Cobb angle was (13.53±14.87)°, and postoperative Cobb angle correction rate was (80.90±17.36) %. The postoperative Cobb angle correction rate in the group with spinal flexibility≥30% was higher than that in the group with spinal flexibility＜30% (［86.97±15.39］% vs ［74.41±17.74］%; t＝2.802, P＝0.011). The proportions of patients in the spinal flexibility≥30% and ＜30% groups receiving osteotomy and orthopedic surgery were 61.0% (25/41) and 80.5% (33/41), respectively (χ²＝3.770, P＝0.052). Conclusion For patients with moderate to severe scoliosis, preoperative weight-bearing whole spine scanography with supine position under traction and whole spine scanography with erect position can provide data such as spinal flexibility and Cobb angle for the selection of surgical options.

Abstract:Objective To explore the prediction and correction methods of postoperative intraocular pressure (IOP) after small incision lenticule extraction (SMILE). Methods In this retrospective and prospective study, 90 patients (180 eyes) who underwent SMILE in the ophthalmology department of our hospital from Dec. 2019 to Dec. 2021 were enrolled. From them, 30 eyes were selected randomly as validation set, and the remaining 150 eyes were included as training set. A prospective selection of 51 patients (102 eyes) who received SMILE from Jan. to Sep. 2022 was included as test set. Firstly, IOP of the training set was analyzed 3 d before surgery, 1 week, 1 month, 3 months and 6 months after surgery to determine the IOP-stable phase and the amount of change in IOP (ΔIOP). Then, preoperative algebraic sum of sphero-cylinder (SC), spherical diopter, diopter of cylinder, IOP, central corneal thickness (CCT), mean corneal curvature (Km, the mean of flat corneal curvature ［K1］ and steep corneal curvature ［K2］), anterior chamber depth (ACD), amount of change of each parameter in postoperative IOP stability (ΔCCT, ΔKm, ΔK1, ΔK2, and ΔACD), and individual factors were selected, and the factors associated with ΔIOP were subsequently incorporated into the regression models. Finally, formulas suited for prediction and correction of IOP after clinical SMILE were developed and validated for efficacy. Results The postoperative IOP was all decreased after SMILE. There were no significant differences among 1-week, 3-month or 6-month postoperative IOP, but the differences of IOP between 1 month and the rest of time periods were statistically significant (all P＜0.05). Factors were selected and the following best regression equation was established: ΔIOP＝0.459×IOP_preoperative (mmHg)－0.183×SC (D)－0.041×age (year)＋1.292×ΔACD (mm)－1.270 (adjusted R²＝0.533, P＜0.001). Preoperative IOP and SC were included only, the simplified equation was: ΔIOP＝0.496×IOP_preoperative (mmHg)－0.194×SC (D)－2.952 (adjusted R²＝0.498, P＜0.001). Predictive and adjusted formulas obtained through rounding and intercept correction were as follows: IOP_{postoperative} (predicted) (mmHg)＝0.5×IOP_preoperative (mmHg)＋0.2×SC (D)＋3, IOP_{postoperative} (corrected) (mmHg)＝ IOP_{postoperative} (mmHg)＋0.5×IOP_preoperative (mmHg)－0.2×SC (D)－3. After internal validation and external testing, the prediction performance of the simplified formulas was good. Conclusion The IOP tends to stabilize at 3 months after SMILE, and the ΔIOP is correlated with diopter. Postoperative IOP can be rapidly predicted and corrected using simplified formulas.

Abstract:Objective To explore the status of chronic diseases and differences in key demographic characteristics among the Hakka elderly in Fujian, China. Methods A convenience sampling method was used to conduct a questionnaire survey of the Hakka elderly (aged ≥60 years) in Ninghua County, Fujian, China to collect the data on the demographic characteristics and the prevalence of chronic diseases. SPSS 25.0 software was used to conduct chi-square tests and binary logistic regression. Results A total of 1 262 individuals were included in the final analysis. The overall prevalence of chronic diseases in the Hakka elderly was 52.54% (663/1 262), and the prevalence of chronic comorbidities was 21.79% (275/1 262). People who were overweight (odds ratio ［OR］＝2.29), obese (OR＝2.16), with an average household income between 15 001 and 30 000 yuan (OR＝1.61) had a higher prevalence of chronic diseases. People who were overweight (OR＝3.81), obese (OR＝4.99) and widowed (OR＝1.63) had a higher prevalence of chronic comorbidities. Those who had an education of primary school and above (primary school: OR＝0.50; junior high school and above: OR＝0.57), living with spouse (OR＝0.41) and living with one child (OR＝0.42) had a lower prevalence of chronic diseases. Conclusion High prevalence of chronic diseases and chronic comorbidities are found among the Hakka elderly in Fujian, China. People who are overweight, obese, poorly educated or live alone have a higher risk of chronic disease or chronic comorbidities. The government, society and families should focus on these groups and adopt targeted chronic disease control and management measures to improve the overall quality of life of the Hakka elderly.

Abstract:Objective To conduct sequencing and bioinformatics analysis of mRNA from mouse macrophages regulated by Mn^2＋, screen out differentially expressed genes, and analyze their biological functions, so as to explore the regulatory effect of Mn^2＋ on mouse macrophages. Methods MnCl₂ and NaCl were used to treat mouse peritoneal macrophages for 24 h, respectively. The mRNA-seq method was used to screen for the differentially expressed genes of macrophages regulated by Mn^2＋, then the differentially expressed genes were analyzed with the Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analyses, and the key differentially expressed genes were verified by quantitative polymerase chain reaction (qPCR). Results A total of 1 637 differentially expressed genes were obtained by integrating database information and analyses, including 912 upregulated genes and 725 down-regulated genes. GO enrichment analysis showed that these differentially expressed genes had biological activities, such as phagocytosis, cell proliferation and differentiation, and regulation of transcription factors. The KEGG pathway was mainly enriched in phosphatidylinositol 3-kinase-protein kinase B and nuclear factor κB signaling pathways. The top 10 genes associated with immunity and with the most significant differences were Fc receptor, immunoglobulin G, high affinity Ⅰ (Fcgr1), sterile α motif domain containing 11 (Samd11), activity regulated cytoskeleton-associated protein (Arc), G protein-coupled receptor 35 (Gpr35), small proline-rich protein 2H (Sprr2h), Wnt family member 4 (Wnt4), integral membrane protein 2A (Itm2a), atonal bHLH transcription factor 8 (Atoh8), ubiquitin conjugating enzyme E2C (Ube2c) and small proline rich protein 2B (Sprr2b). The qPCR verification results of the 10 genes were consistent with the trend of mRNA sequencing analysis. Conclusion The screening of the differentially expressed genes from mouse macrophages regulated by Mn^2＋ based on mRNA-seq data and the analyses of GO and KEGG enrichment show that Mn^2＋ has an immunoregulation effect on mouse macrophages.

Abstract:Neuropsychological symptoms of acute inflammatory diseases have gradually attracted the attention of clinicians. Guillain-Barré syndrome (GBS) is a post-infectious autoimmune polyneuropathy which affects motor, sensory, and autonomic nerves. It is one of the most common neurological disorders resulting in acute paralysis. With the in-depth understanding of the disease, the neuropsychological symptoms of GBS have gradually attracted attention. However, researches on the neuropsychological symptoms of GBS are still scarce and there are still no diagnostic criteria and only few studies focusing on the treatment. In addition, the influence of neuropsychological symptoms on the rehabilitation and social function of GBS patients could not be ignored. This article summarized the characteristics, diagnosis and treatment progress of GBS patients with neuropsychological symptoms such as fatigue, anxiety, depression, cognitive disorders, and sleep disorders. Neurologists should improve the understanding of the neuropsychological symptoms of GBS patients and attach importance to the evaluation and intervention of neuropsychological symptoms of GBS.

Abstract:Tumor cells evade the body’s immune system by expressing immune checkpoints. By blocking these immune checkpoints, immune checkpoint inhibitors can promote anti-tumor immune response and elicit strong anti-tumor effects. As an innate immune checkpoint, CD47 is widely overexpressed in different malignant tumors. It assists tumor cells to evade immune surveillance and attack by interacting with signal regulatory protein α (SIRPα) on macrophages to inhibit the phagocytosis of tumor cells by macrophages. Blocking CD47/SIRPα signaling axis can activate the phagocytosis of macrophages on tumor cells and promote the anti-tumor immune response. However, due to the complex tumor micro-environment, blocking a single signaling pathway on immune cells only has limited or mild effects. Moreover, the tumor response rate is low with drug targeting the CD47/SIRPα signaling axis alone and there are serious adverse reactions. In order to overcome these problems and improve the antitumor effect, combining drugs targeting the CD47/SIRPα signaling axis with other anti-tumor therapies becomes one of the most effective strategies. This article reviews the recent research progress on the CD47/SIRPα signaling axis and combination therapy strategies based on drugs targeting the CD47/SIRPα signaling axis.

Abstract:As a classic prescription of traditional Chinese medicine, Danggui Buxue decoction (DBD) is mainly used for invigorating qi and promoting blood, with the following specific functions: promoting hematopoiesis, protecting kidney tissue, regulating immunity, anti-fibrosis, anti-tumor, anti-depression and so on. Relevant studies in recent 15 years on promoting hematopoietic functions by DBD have been collected in this review. The chemical components of DBD were summarized and the influences of DBD on hematopoietic system were reviewed, with focus on promoting the formation of hematopoietic stem cells and peripheral blood cells, inhibiting the senescence of hematopoietic stem cells, improving the bone marrow hematopoietic microenvironment, and regulating intestinal flora, immune system and extramedullary organ hematopoiesis.

Abstract:A series of traditional Chinese medicine decoction have been proved to inhibit pathological neovascularization in both clinical practice and laboratory experiment. Small molecules of traditional Chinese medicine are the active components of compound decoction of traditional Chinese medicine. Some small molecules of traditional Chinese medicine can inhibit neovascularization by suppressing the expression of vascular endothelial cell growth factors in different ways, which provides new ideas for the treatment of angiogenesis diseases. Neovascularization plays an important role not only in retinal angiogenesis diseases such as diabetic retinopathy, but also in the development and progression of malignant tumors. In this review, the process and the mechanism of neovascularization were briefly described, and the mechanisms of inhibiting neovascularization by flavonoids, saponins, alkaloids and other small molecules of traditional Chinese medicine were reviewed in detail.

Abstract:Osteoclasts are multinucleated macrophages derived from mononuclear hematopoietic myeloid cells, and their activation plays a very important role in the development and progression of inflammatory bone destruction and osteoporosis. The differentiation and function of osteoclasts are regulated by a variety of cytokines and growth factors. Previous studies have shown that transforming growth factor β1 (TGF-β1) and its downstream signal transduction proteins Smad2/3 and Smad1/5 can promote or inhibit the differentiation, development and maturation of osteoclasts, and its mechanism is related to regulating the receptor activator of nuclear factor κB ligand (RANKL)/receptor activator of nuclear factor κB factor (RANK) signaling pathway and its downstream mediators. This paper mainly reviews the roles of TGF-β1/Smad signaling pathway in the differentiation and development of osteoclasts.

Abstract:Telesurgery, part of telemedicine, uses wireless networking and robotics to allow surgeons to perform operations on patients in remote locations. This technology can not only alleviate surgeon shortage problem, but also reduce the adverse effects caused by geographical barriers, allowing timely and effective surgery and reducing the cost of surgical treatment and the risk during transport. The development of telesurgery requires the dual support of 5G network technology and surgical robotic technology. This article analyzes the applications and limitations of 5G network technology and computer-assisted technology in telesurgery, summarizes the current status and innovative development in telesurgery, and provides further insights for its development.

Abstract:Objective To explore the feasibility of mobile blood bank in blood support for large surface warship and the operation mode of emergency blood collection and supply through emergency blood collection and supply drill. Methods The emergency blood collection and supply drill was developed in advance, and the feasibility of the plan was tested by organizing practical exercises during offshore training. At the same time, the time period and existing problems of each step in the drill were recorded. Results It took about 35 min from the time when the blood collection personnel was notified by the radio to the time when he/she completed the blood type identification, cross matching and whole blood collection. The blood collection personnel had proven skills, and no adverse reactions occurred in the blood donors. Conclusion The simulation results show that mobile blood bank can be used as a major way of blood support for large surface warships, but it still needs further optimization.

Abstract:Objective To analyze the roles of serum 7 microRNAs (7miRNAs, including miRNA-122, miRNA-192, miRNA-21, miRNA-223, miRNA-26a, miRNA-27a, and miRNA-801) alone or in combination with α-fetoprotein (AFP) in diagnosing hepatocellular carcinoma (HCC). Methods A total of 249 patients who were admitted to our hospital from Jan. 2021 to Jun. 2021 were enrolled, including 163 patients with confirmed HCC (HCC group) and 86 patients without HCC (non-HCC group). The serum levels of 7miRNAs and AFP were measured in the 2 groups, and based on the established clinical criteria (7miRNAs≥－0.5 and/or AFP≥20 ng/mL were positive), the sensitivity, specificity, positive predictive value and negative predictive value of the 2 indicators were calculated for the diagnosis of HCC alone and in combination. The receiver operating characteristic curve was used to analyze the diagnostic value of the 2 indicators used alone or in combination for HCC. Results Among 249 patients, the levels of 7miRNAs and AFP in the HCC group were significantly higher than those in the non-HCC group (both P＜0.01). The sensitivities of serum 7miRNAs, AFP and their combination were 75.46%, 57.06% and 87.12% for the diagnosis of HCC, respectively; the specificities were 74.42%, 94.19% and 69.77%, respectively; the positive predictive values were 84.83%, 94.90% and 84.52%, respectively; the negative predictive values were 61.54%, 53.64% and 74.07%, respectively; and the area under curve values were 0.787, 0.819 and 0.864, respectively. Conclusion The combined detection of serum 7miRNAs and AFP has higher diagnostic value than that of AFP used alone for HCC.

Abstract:Objective To explore whether there are short-term electrocardiogram characteristics which may serve as a biomarker for cumulative fatigue. Methods The electrocardiogram signals of 14 students (7 males and 7 females, with age ranging 19-23 years) from the University of Shanghai for Science and Technology, who were participating in the national electronic design competition for college students, were dynamically tracked. The scores of subjective fatigue scale and sleep duration were collected, and 13 characteristic electrocardiogram items were calculated, including heart rate variability, electrocardiogram entropy, high and low frequency values, and average RR interval. The difference between the electrocardiogram items was compared using the Wilcoxon signed-rank test between awakening and fatigue states. Results The subjective fatigue level was increased during lack of sleep, and the high frequency value of short-term electrocardiogram characteristics, the ratio of high to low frequency values and the Poincaré plot SD2 were significantly different between awakening and fatigue states (all P＜0.05). Conclusion Some short-term electrocardiogram characteristics could be used for the detection of cumulative fatigue.

Abstract:Objective To explore the role of systemic immune-inflammation index (SII) combined with monocyte to high density lipoprotein-cholesterol ratio (MHR) in predicting myocardial injury in patients with acute carbon monoxide poisoning (ACOP). Methods A total of 113 ACOP patients who were admitted to Department of Emergency of Harrison International Peace Hospital Affiliated to Hebei Medical University, Department of Emergency of Affiliated Hospital of Hebei University, and Department of Emergency of North China University of Science and Technology Affiliated Hospital from Jan. 2020 to Mar. 2022 were enrolled and divided into myocardial injury group (n＝30) and non-myocardial injury group (n＝83). The levels of SII, MHR, C reactive protein (CRP), cardiac troponin I (cTnI) and creatine kinase isoenzyme (CK-MB) were detected at admission and 12 h after admission. The independent risk factors of myocardial injury in ACOP patients were analyzed by logistic regression. The early predictive values of SII, MHR and their combination for myocardial injury in ACOP patients were analyzed by receiver operating characteristic curves. Results The levels of SII, MHR and CRP of patients in the myocardial injury group were higher than those in the non-myocardial injury group at admission, and the levels of SII, MHR, CRP, cTnI and CK-MB of patients in the myocardial injury group were higher than those in the non-myocardial injury group at 12 h after admission (all P＜0.001). The elevated levels of SII, MHR and CRP were risk factors for myocardial injury in ACOP patients (odds ratio＝7.248, 5.733, 2.496, all P＜0.05). The AUC value, sensitivity and specificity of SII combined with MHR were higher in predicting myocardial injury in ACOP patients at admission (0.876, 0.867 and 0.766, respectively). Conclusion The combination of SII and MHR has early predictive value for myocardial injury in ACOP patients.

Abstract:

Abstract: