Abstract:Skeletal system and immune system are 2 important systems for maintaining human life. Osteoporosis is a complex pathological change of bone tissue. Immune system disorders have become the cause of osteoporosis through affecting the proliferation and differentiation of osteoblasts and osteoclasts. Innate immunity, adaptive immunity, and cytokines play crucial roles in bone resorption and remodeling by regulating the signaling pathways of osteoblasts and osteoclasts. Therefore, immunoporosis has emerged for studying the inseparable relationship between osteoporosis and immune system. This article reviews the research progresses on immunoporosis, aiming to provide references for immunotherapy of osteoporosis.

Abstract:Objective To explore the relationship between triglyceride-glucose index (TyG) and acute ischemic stroke with large vessel occlusion (AIS-LVO) of anterior circulation. Methods A retrospective study was conducted on patients with anterior circulation AIS-LVO who underwent emergency endovascular thrombectomy at Neurovascular Center of The First Affiliated Hospital of Naval Medical University from Jan. 2018 to Dec. 2019. According to modified Rankin scale (mRS) score 90 d after operation, the patients were assigned to favorable outcome group (mRS score 0-2) or unfavorable outcome group (mRS score 3-6), and the TyG was compared. According to the median of TyG, the patients were assigned to low-TyG group (TyG＜ 8.57) or high-TyG group (TyG≥8.57), and the clinical data, laboratory indexes, and imaging characteristics were compared. Receiver operating characteristic curve was used to evaluate the predictive value of TyG for poor prognosis. Results A total of 135 patients were enrolled, with 72 in the favorable outcome group and 63 in the unfavorable outcome group. The TyG of the unfavorable outcome group was significantly higher than that of the favorable outcome group (8.82±0.63 vs 8.43±0.60, P＜0.001). There were 67 patients in the low-TyG group and 68 in the high-TyG group. Compared with the low-TyG group, the proportion of patients with hyperlipidemia history (P＝0.003), systolic blood pressure at admission (P＝0.018), fasting blood glucose level (P＜0.001), and triglyceride level (P＜0.001) were significantly higher in the high-TyG group, the infarct core volume was significantly larger (P＝0.025), the high density lipoprotein-cholesterol level was significantly lower (P＝0.013), and the mRS score 90 d after operation was significantly higher (3 ［1, 5］ vs 1 ［0, 5］, P＝0.049). The TyG had certain predictive value for poor prognosis in anterior circulation AIS-LVO patients (area under curve value＝0.662, 95% confidence interval 0.571-0.753). Conclusion TyG is elevated in anterior circulation AIS-LVO patients with poor prognosis, and may be a potential prognostic indicator for anterior circulation AIS-LVO patients.

Abstract:Objective To explore the development trajectories of cognitive function in patients with acute ischemic stroke and its latent class predictors. Methods Cluster convenience sampling was used to enroll acute ischemic stroke patients (n＝128) who were hospitalized in Neurovascular Center of The First Affiliated Hospital of Naval Medical University and Stroke Center of Air Force Hospital of PLA Eastern Theater Command from Jun. 2019 to Mar. 2020. Montreal cognitive assessment (MoCA) was used to assess the cognitive function of the patients, and baseline data (such as demographic data, disease-related data, and cognitive function) were collected during the acute hospitalization period. The cognitive function was assessed 3 and 6 months after stroke. Latent growth mixture modeling was used to identify cognitive function development trajectories, and multiple logistic regression was used to analyze predictors of different classes of development trajectories. Results Three latent classes of cognitive function development trajectories were identified in patients with acute ischemic stroke: high-level cognitive maintenance group (n＝98, 76.6%), low-level cognitive improvement group (n＝20, 15.6%), and medium-level cognitive decline group (n＝10, 7.8%). Multiple logistic regression analysis showed that education level, marital status and dysphagia were independent predictors of cognitive function development trajectories in acute ischemic stroke patients (all P＜0.05). Conclusion There is heterogeneity in the development trajectories of cognitive function in acute ischemic stroke patients, and medical staff can conduct personalized evaluation and intervention based on the influencing factors of different classes of cognitive function development trajectories.

Abstract:Objective To explore the relationships between social support, positive coping, caregiver burden and family resilience of primary caregivers of first-stroke patients. Methods A questionnaire survey was conducted among 307 primary caregivers of first-stroke patients in 2 tertiary hospitals in Shanghai by convenience sampling method. Social support rating scale, simplified coping style questionnaire, Zarit caregiver burden interview, and family resilience assessment scale were used for questionnaire survey. Pearson correlation analysis and structural equation models were used for data analysis. Results A total of 288 valid questionnaires were collected, and the effective recovery rate was 93.81%. Pearson correlation analysis showed that there was a positive correlation between family resilience and social support, family resilience and positive coping, and social support and positive coping (r＝0.375, 0.627, and 0.277; all P＜0.01), while caregiver burden and social support, caregiver burden and positive coping, and family resilience and caregiver burden were all negatively correlated (r＝－0.203, －0.343, and －0.444; all P＜0.01). The mediating effect model was constructed with positive coping and caregiver burden as mediating variables, social support as independent variables, and family resilience as dependent variables. The results showed that social support could mediate family resilience through positive coping, with a mediating effect of 0.164, accounting for 26.1% of the total effect; social support could also affect the family resilience of the primary caregivers of first-stroke patients through the partial chain mediating effect of positive coping and caregiver burden, with a mediating effect value of 0.032, accounting for 5.1% of the total effect. Conclusion Social support can predict family resilience among primary caregivers of first-stroke patients, and positive coping and caregiver burden play chain mediating roles in the impact of social support on family resilience.

Abstract:Objective To explore the research status and emerging focus of virtual reality (VR) technology in the field of stroke. Methods The global literature of VR technology in the field of stroke from Jan. 2014 to Aug. 2024 was retrieved from the Web of Science Core Collection. Bibliometric software was used to draw a visual knowledge map of authors, institutions, key words, etc. Results After excluding proofreading notices, editorial materials, conference papers, etc., a total of 785 articles were included. Over the past decade, the number of new publications has shown an upward trend. China was the country with the largest total number of publications (130 articles). Lamontagne Anouk (10 articles) and Calabro Rocco Salvatore (10 articles) were tied for the authors with the highest number of publications. The institution and journal with the most literature in this field were McGill University (Canada, 27 articles) and Journal of Neuroengineering and Rehabilitation (60 articles), respectively. The key word analysis and the results of the strongest burst key words indicated that the research focused on upper limb, gait training, motor function, cognitive rehabilitation, post-stroke unilateral spatial neglect, stimulation, motor imagery, cortical reorganization, etc. Conclusion Over the past decade, the application of VR technology has gradually increased in both breadth and depth in the field of stroke, bringing new opportunities and thoughts to stroke rehabilitation. The new forms of VR technology combined with neuromodulation, neuroimaging, brain-computer interfaces, artificial intelligence, and telemedicine may be the future research topics and directions.

Abstract:Objective To observe the changes of myelin sheath in corpus callosum on non-ischemic side after ischemic stroke in rats with cerebral ischemia/reperfusion (I/R) model, and to investigate the effect of vagus nerve stimulation (VNS) on secondary demyelination in I/R model. Methods Forty-two rats were randomly assigned to sham, I/R, or I/R＋VNS groups, with 14 rats in each group. Except for the sham group, the rats in other groups were used to construct I/R model by a middle cerebral artery occlusion thread method. In addition, the rats in the I/R＋VNS group were given repetitive electrical stimulation of the left vagus nerve for 60 min at 30 min after ischemia occlusion. The cerebral infarction volume was observed by 2,3,5-triphenyltetrazolium chloride staining. The expression levels of myelin basic protein (MBP) and myelin-associated glycoprotein (MAG) in the corpus callosum on the non-ischemic side were detected by Western blotting. The integrity and thickness of myelin sheaths in the corpus callosum on the non-ischemic side were observed by Luxol fast blue staining and transmission electron microscopy, respectively. Results Compared with the sham group, the volume of cerebral infarction in the I/R group was increased (P＜0.01). On the 3^rd day after I/R, compared with the sham group, the expression levels of MBP and MAG were significantly decreased (both P＜0.01), the intensity of Luxol fast blue staining was significantly decreased (P＜0.01), and the thickness of the myelin sheath was significantly thinner (g-ratio was increased, P＜0.01) in the corpus callosum on the non-ischemic side. Compared with the I/R group, the expression levels of MBP and MAG in the I/R＋VNS group were significantly increased (both P＜0.05), the intensity of Luxol fast blue staining was significantly increased (P＜0.01), and the thickness of myelin sheath was significantly increased (g-ratio was decreased, P＜0.01) in the corpus callosum on the non-ischemic side. Conclusion Secondary demyelination occurs on the non-ischemic side of the rat corpus callosum after ischemic stroke, and VNS can ameliorate the demyelination.

Abstract:Objective To explore the risk factors for the recurrence of autoimmune pancreatitis (AIP), so as to provide a new reference for its clinical treatment. Methods The clinical data of 198 AIP patients admitted to The First Affiliated Hospital of Naval Medical University from 2014 to 2021 were collected, including 164 patients with type 1 AIP and 34 patients with type 2 AIP. Based on the recurrence status of AIP, the patients were categorized into recurrence group (38 cases) and non-recurrence group (160 cases), and differences between the 2 groups were analyzed. Patients with definite duration of glucocorticoid maintenance therapy were further screened, and logistic regression model and Spearman rank correlation analysis were used to analyze the risk factors of AIP recurrence. Results During the follow-up period, 19.19% (38/198) of AIP patients experienced a relapse. The 1-, 3-, and 5-year cumulative recurrence rates were 6.57%, 9.09%, and 12.63%, respectively, with type 1 AIP demonstrating a significantly higher recurrence rate than type 2 AIP (21.95% ［36/164］ vs 5.88% ［2/34］, P＝0.030). Univariate logistic regression analysis showed that serum low density lipoprotein-cholesterol level (odds ratio ［OR］ ＝0.544, 95% confidence interval ［CL］ 0.321-0.924, P＝0.024) and the duration of glucocorticoid maintenance therapy (OR＝0.797, 95% CI 0.704-0.902, P＜0.001) were the potential factors of AIP recurrence in 112 patients with definite data on the duration of glucocorticoid maintenance therapy. Multivariate logistic regression analysis showed that the duration of glucocorticoid maintenance therapy was independently associated with AIP recurrence (OR＝0.813, 95% CI 0.713-0.926, P＝0.002). Spearman rank correlation analysis further demonstrated a negative correlation between the duration of glucocorticoid maintenance therapy and AIP recurrence (r＝－0.545, P＜0.001). Additionally, receiver operating characteristic curve analysis indicated that the duration of glucocorticoid maintenance therapy had good predictive effect on AIP recurrence, with an area under curve value of 0.873 (95% CI 0.800-0.945, P＜0.001). Conclusion Long-term regular glucocorticoid therapy is an independent protective factor against AIP recurrence, and it can significantly reduce the recurrence of AIP.

Abstract:Objective To compare the clinical efficacy of transforaminal lumbar interbody fusion under unilateral biportal endoscopy (UBE-TLIF) and traditional posterior lumbar interbody fusion (PLIF) in treating single-segment degenerative lumbar spondylolisthesis with lumbar spinal stenosis (DLS-LSS). Methods The clinical data of 85 patients diagnosed with DLS-LSS who underwent surgery between Jan. 2020 and Jan. 2022 in our hospital were retrospectively analyzed. Patients were assigned to UBE-TLIF group (46 cases) and PLIF group (39 cases) based on the surgical procedure. The general characteristics, perioperative data, radiological parameters, and clinical efficacy indicators were analyzed. Results There were no significant differences in baseline characteristics, preoperative radiological parameters, pain visual analogue scale (VAS) score, or Oswestry disability index (ODI) score between the 2 groups (all P＞0.05). Compared with the PLIF group, the UBE-TLIF group had significantly longer operation time (［156.42±26.65］ min vs ［141.36±21.46］ min, P＝0.006), significantly less operation blood loss (［170.15±10.87］ mL vs ［203.15±15.67］ mL, P＜0.001), and significantly shorter hospital stay (［6.73±2.42］ d vs ［9.61±2.56］ d, P＜0.001). The UBE-TLIF group had significantly smaller lumbar lordosis and segmental angle 3 months postoperatively (［42.52±8.57］° vs ［46.61±7.31］°, ［10.93±2.59］° vs ［12.16±3.05］°) and at final follow-up (［41.35±7.46］° vs ［44.62±6.42］°, ［10.65±2.43］° vs ［11.87±2.53］°) compared with the PLIF group (all P＜0.05). The fusion rate was significantly lower in the UBE-TLIF group compared with the PLIF group 3 months after operation (34.78% ［16/46］ vs 58.97% ［23/39］, P＜0.05), with no significant difference at final follow-up (93.48% ［43/46］ vs 94.87% ［37/39］, P＞0.05). The VAS score and ODI score 3 months after operation were significantly lower in the UBE-TLIF group compared with the PLIF group (2.43±0.92 vs 3.12±1.03, 26.81±9.14 vs 33.35±8.76, both P＜0.01), with no significant differences at final follow-up (both P＞0.05). Conclusion As a minimally invasive surgical technique, UBE-TLIF has the advantages of minimal trauma, fast recovery, mild postoperative pain, and a reliable fusion rate. It is an effective treatment for DLS-LSS and deserves to be promoted.

Abstract:Objective To explore the status of working ability of patients with ankylosing spondylitis (AS) in China from multi-center, multi-level and multi-dimensional perspectives, and analyze the influencing factors of working ability in AS patients, so as to improve the outcome of working ability disorder in AS patients. Methods The demographic data, working ability and disease-related information of 253 AS patients admitted to 10 hospitals in 9 centers in China from Mar. 2022 to Sep. 2023 were collected. Work productivity and activity impairment questionnaire was used to investigate the working status. The influencing factors of working ability disorder were analyzed, and the correlations of the work ability with the severity of disease, self-assessment, and mental health status were discussed. Results A total of 253 patients with AS were enrolled, of which 197 (77.87%) were employed, 76 (30.04%) were in normal working status, and 177 (69.96%) had disorder in working ability. Multivariate logistic regression analysis showed that the course of AS, Bath ankylosing spondylitis functional index, Bath ankylosing spondylitis measurement index, functional assessment of chronic illness therapy-fatigue, ankylosing spondylitis disease activity score-erythrocyte sedimentation rate, Assessment of Spondyloarthritis International Society health index, depression, anxiety, and patient global assessment were important factors affecting the working ability of patients. Conclusion There is a high proportion of work ability disorder in Chinese AS patients, and the severity of the disease, psychological state and self-reported outcome are closely related to the status of work ability.

Abstract:Objective To analyze the epidemic status of breast cancer globally and in China based on gender (female), age, and human development index (HDI) according to the Global cancer statistics 2022 published by the International Agency for Research on Cancer. Methods The epidemiological data of breast cancer from 185 countries and territories were sourced from the GLOBOCAN 2022 database. The HDI data were compiled based on the Human development report 2022 published by the United Nations Development Programme. The epidemiological data were stratified by age, gender, and HDI to describe the prevalence of breast cancer globally and in China. Pearson correlation analysis was used to evaluate the correlation of standardized incidence rate (SIR), standardized mortality rate (SMR) and mortality-to-incidence ratio (M/I) with HDI. Results The data of 175 countries and territories were included. The number of breast cancer incident cases worldwide was 2 297 000 in 2022, ranking the 2^nd only to lung cancer, with an SIR of 46.8 per 100 000 (ranking the 1^st in the world). The number of breast cancer deaths globally was 666 000, ranking the 4^th among all cancer deaths, with an SMR of 12.7 per 100 000 (ranking the 2^nd worldwide). In China, the number of breast cancer incident cases was 357 000, ranking the 6^th among all cancers, accounting for 15.5% of the global breast cancers, with an SIR of 33.0 per 100 000 (ranking the 2^nd among all cancers in China). The number of breast cancer deaths in China was 75 000, ranking the 7^th among all cancer deaths, accounting for 11.3% of the global breast cancer deaths, with an SMR of 6.1 per 100 000 (ranking the 6^th among all cancer deaths in China). For females around the world, the number of breast cancer incidents and deaths, SIR, and SMR ranked the 1^st among all cancers. For Chinese females, both the incident number of breast cancer and SIR ranked the 2^nd, while the deaths and SMR ranked the 5^th and the 4^th, respectively. SIR was positively correlated with HDI (r＝0.76, P＜0.01), M/I was negatively correlated with HDI (r＝－0.89, P＜0.01), while SMR was not correlated with HDI (r＝－0.09, P＝0.23). The incidence of breast cancer worldwide and in China increased with age from 25 to 29 years old. The number of breast cancer deaths in the world increased with age from 30 years old, peaked at 50-59 years old, and declined after 70 years old. The breast cancer deaths in China showed 2 small peaks at the age of 50-54 and 65-69 years old, and gradually decreased after 70 years old. The age-dependent trend of SIR varied in different countries and territories with different HDI levels, as well as globally and in China, whereas SMR continued to increase with age. Conclusion The disease burden of breast cancer is serious globally and in China. Especially in females, both SIR and SMR rank the 1^st in the world; although they rank the 2^nd and the 4^th, respectively, in China, the number of incidents and deaths cannot be ignored. HDI is positively correlated with SIR and negatively correlated with M/I, however, with no correlation with SMR. The SIR in countries and territories with different HDI levels changes differently with age, while SMR increases with age in all.

Abstract:Objective To evaluate the clinical efficacy of artificial intelligence (AI)-assisted imaging diagnostic trials using multi-reader multi-case (MRMC) design, so as to provide a scientific basis for clinical evaluation of imaging diagnostic trials. Methods The MRMC design, widely used in imaging diagnostic trials, was adopted in this study. The Obuchowski-Rockette (OR) method of MRMC design was detailed, including model construction and test methods. A case study was conducted, collecting imaging data of 200 subjects from 3 hospitals, with 133 cases of rib fractures and 68 cases of non-rib fractures. Three radiologists reviewed all CT images of the subjects. The area under curve (AUC) value, sensitivity and specificity in detecting rib fractures between 2 reading modalities (radiologists with AI assistance vs radiologists reading independently) were compared. Results The AI-assisted reading group had an AUC value of 0.958, while the radiologist-independent reading group had an AUC value of 0.902, showing a significant difference (P＜0.001). The overall sensitivity and specificity of the AI-assisted reading group were 0.970 and 0.946, respectively; while the sensitivity and specificity of the radiologist-independent reading group were 0.838 and 0.966, respectively. The difference of sensitivity between groups was 0.131 (95% confidence interval ［CL］ 0.091-0.171), and the difference of specificity was －0.020 (95% CI －0.059-0.020), indicating a significant difference in sensitivity but not in specificity between AI-assisted and radiologist-independent reading groups. Both groups had positive likelihood ratios (＋LR) greater than 10 and negative likelihood ratios (－LR) less than 0.2, with positive predictive values approaching 1, suggesting that the diagnostic accuracy of the AI-assisted imaging diagnostic trials was high. Conclusion The AI-assisted reading method demonstrates a significant advantage in enhancing diagnostic efficiency, not only improving the diagnostic accuracy and detection rate of rib fractures, but also improving the work efficiency of radiologists and optimizing hospital services.

Abstract:Sepsis refers to a life-threatening organ dysfunction caused by a dysregulated host response to infection, with persistently high morbidity and mortality, posing a significant healthcare burden. As integral components of innate and adaptive immunity, macrophages exhibit high plasticity and can differentiate into distinct phenotypes (M1 pro-inflammatory and M2 anti-inflammatory) in response to various environmental stimuli, playing crucial roles in both the hyperinflammatory phase and late immunosuppressive phase of sepsis. The metabolic profile of M2 macrophages has gradually become a research focus, and it is regulated by a variety of enzymes and signaling pathways, including adenosine 5'-monophosphate-activated protein kinase, peroxisome proliferator-activated receptor and protein kinase RNA-like ER kinase pathways. These pivotal signaling pathways and enzymes can promote the polarization of M2 macrophages and enhance their anti-inflammatory functions by modulating the metabolism of glucose, lipid, and amino acid, thereby conferring protective effects against sepsis and providing new ideas for the targeted treatment.

Abstract:Alzheimer’s disease (AD) is the most common neurodegenerative disease in the elderly, and its main pathological manifestations include senile plaques formed by β-amyloid deposition and neuronal fibrillar nodules formed by hyperphosphorylation of tau proteins. Lysosome is an important organelle in eukaryotic cells, containing a variety of hydrolytic enzymes that can break down proteins and other biomolecules. It is closely related to intracellular transport and autophagy, and is important for maintaining cellular homeostasis. This review summarizes the interaction between lysosomal dysfunction and the development and progression of AD and the potential therapeutic mechanisms in treating AD by regulating and restoring the functions of lysosomes. Lysosomal dysfunction can lead to neurodegenerative diseases such as AD. Modulation of lysosomal function is a promising treatment strategy for AD. It is expected that more drugs and therapeutic regimens based on this mechanism can be used in the clinical treatment for AD patients in the future.

Abstract:Imaging modalities play an important role in predicting the efficacy of neoadjuvant chemotherapy for breast cancer, and different imaging modalities have their own advantages and value. In this review, the performance of mammography, magnetic resonance imaging (MRI), ultrasound, and positron emission tomography in predicting the efficacy of neoadjuvant chemotherapy for breast cancer was compared. Among them, MRI, especially dynamic contrast-enhanced MRI, and the combination of imaging omics and artificial intelligence, has shown high sensitivity and specificity, and has gradually become the preferred examination method. With the continuous progress of technology and research, these imaging modalities are expected to play more important roles in the precise and individualized treatment of breast cancer.

Abstract:Wound healing is a complex and highly coordinated physiological process, involving the interaction of various cell types, growth factors, and extracellular matrix. Its goal is to repair damaged tissue and restore skin integrity and function. However, various internal and external factors can lead to delayed or abnormal wound healing, causing significant pain and economic burdens for patients. Therefore, it is of great clinical significance to develop safe and effective treatments to promote wound healing. In recent years, research on natural products in the field of wound healing has attracted widespread attention, and berberine, a biological alkaloid with multiple pharmacological activities, has garnered considerable attention for its remarkable effects in promoting wound healing. This article provides an in-depth review on the progress in the application of berberine in wound healing from multiple perspectives.

Abstract:As a sub-discipline of field surgery, trauma surgery of naval warfare focuses on the treatment of marine casualties, which is the extension and application of field surgical theories and techniques in the context of naval warfare. Informatization and 3-dimension have been the basic features of modern naval warfare. With the extensive use of high-tech weapons, maritime combat styles and security needs have undergone profound changes. The complexity and diversity of marine trauma injuries have created new opportunities and challenges for the development of trauma surgery. This paper analyzes the marine trauma under the conditions of modern warfare, the characteristics of marine trauma surgical care, and the medical evacuation system of casualty care in naval battle, aiming to promote the research of naval medical support and the development of field surgery.

Abstract:Objective To analyze the influencing factors of diabetic cardiovascular autonomic neuropathy (DCAN) secondary to type 2 diabetes mellitus (T2DM). Methods A total of 63 T2DM patients admitted to Department of Endocrinology in our hospital from Nov. 1, 2022 to Nov. 30, 2023 were enrolled. All patients were examined by cardiovascular autonomic nervous system. According to the results, they were assigned to DCAN group or non-DCAN group. Baseline data and laboratory parameters were recorded for each group. Logistic regression analysis was used to identify the influencing factors of DCAN secondary to T2DM, and receiver operating characteristic (ROC) curve analysis was used to study the predictive value of the influencing factors on DCAN. Results There were 32 (50.79%) patients in the DCAN group and 31 (49.21%) patients in the non-DCAN group. The mean age of the patients was significantly older in the DCAN group than in the non-DCAN group (P＝0.002). Logistic regression analysis showed that age was a risk factor for DCAN secondary to T2DM (odds ratio＝1.095, 95% confidence interval 1.029-1.166, P＝0.04). The ROC curve showed that the area under curve value of age predicting DCAN was 0.718, and the best diagnostic value was 58.5 years old, with a sensitivity of 0.719 and a specificity of 0.645. Conclusion Age is a risk factor for DCAN secondary to T2DM, and an increase in age leads to a higher positive rate of DCAN.

Abstract:Objective To investigate the corrective effect of phacoemulsification with intraocular lens implantation combined with limbal relaxing incision (LRI) on cataract patients with corneal astigmatism. Methods A total of 39 patients (41 eyes) with cataract complicated by corneal astigmatism (the astigmatism was －2.0 to －0.5 D) who visited Department of Ophthalmology of The First Affiliated Hospital of Naval Medical University from Sep. 2023 to May 2024 were enrolled. During phacoemulsification with intraocular lens implantation, LRI was performed to correct corneal astigmatism. Preoperative corneal astigmatism was measured using corneal topography and IOLMaster. Corneal astigmatism was re-examined 1 and 3 months after surgery, and Alpins method was used to analyze the changes of corneal astigmation before surgery and 1 month after surgery. The primary vector parameters, such as target induced astigmatism vector (TIA), surgically induced astigmatism vector (SIA), difference vector (DV), correction index and flattening index (FI), were observed. Results The preoperative corneal astigmatism was (－1.07±0.27) D, which was decreased to (－0.53±0.23) D 1 month postoperatively and (－0.55±0.24) D 3 months postoperatively (both P＜0.05). Vector analysis of corneal astigmatism showed that the TIA was (1.07±0.27) D, SIA was (0.99±0.42) D, DV was (0.53±0.24) D; correction index was 0.93±0.36 (the ideal value is 1), suggesting slight undercorrection; the median of the angle of error had an absolute value of 18.15°, and the interquartile range was 15.19°; and the flattening effect was (0.70±0.45) D, the FI was 0.65±0.42, and the success rate was (50.42±19.29)%. Conclusion The combination of LRI with cataract surgery for correcting corneal astigmatism has demonstrated favorable corrective outcomes, especially for the correction of low to moderate corneal astigmatism.

Abstract:Objective To investigate the relationship between internet addiction and SIOSS score, and to examine the mediating role of impulsivity and the moderating role of mental health level. Methods A total of 393 college students were tested with internet addiction scale, Barratt impulsiveness scale-version 11, SIOSS and symptom checklist 90 to establish a moderated mediation model. Results After adjusted for age, internet addiction tendency had a positive predictive effect on SIOSS score (β＝0.523, P＜0.01). Impulsivity played a partial mediating role in the relationship between internet addiction and SIOSS score, with a mediating effect value of 0.087 (45.72%). The first half of the mediating effect of internet addiction→impulsivity→SIOSS score was moderated by mental health level (β＝－0.118, P＜0.001). The predictive effect of internet addiction on impulsivity was stronger in individuals with good mental health level (with the indirect effect value of 0.619 9±0.048 7) compared with the individuals with poor mental health level (with the indirect effect value of 0.439 5±0.048 5). Conclusion Internet addiction can increase SIOSS score by enhancing individual impulsivity, but this effect is more pronounced in individuals with good mental health and then affect SIOSS score.

Abstract: