人工智能在病理诊断领域的纵深发展:从应对挑战到重塑未来
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国家自然科学基金(82173306,82473085).


In-depth development of artificial intelligence in pathological diagnosis: from addressing challenges to reshaping the future
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Supported by National Natural Science Foundation of China (82173306, 82473085).

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    摘要:

    作为现代医学诊断的基石,病理学正面临人力资源短缺、诊断主观性强和工作流程效率低下等多重挑战。人工智能(AI)凭借其在图像识别、模式分析和大数据处理等方面的优势正逐步融入病理诊断领域,推动其向数字化、智能化方向发展。本文系统回顾了AI在病理学中的发展历程,从早期的监督学习验证,到弱监督学习突破“标注瓶颈”,再到当前基于自监督和多模态的基础模型兴起,展示了AI在提升诊断一致性、优化工作流程、预测分子特征及预后等方面的广泛应用。AI不仅增强了病理诊断的客观性和效率,还推动了计算病理组学等新兴交叉学科的发展,为实现精准医疗提供了有力支撑。尽管在临床落地过程中仍面临数据标准化、监管审批等挑战,但AI与病理学的深度融合正开启一个人机协同、智能诊断的新时代。

    Abstract:

    As the cornerstone of modern medical diagnosis, pathology is facing multiple challenges such as workforce shortages, strong diagnostic subjectivity, and inefficient workflows. With advantages in image recognition, pattern analysis, and big data processing, artificial intelligence (AI) is increasingly being integrated into the field of pathological diagnosis, driving its transition toward digitization and intelligence. This article systematically reviews the development of AI in pathology, from early supervised learning validation to weakly supervised learning overcoming annotation bottlenecks, and the recent rise of self-supervised and multimodal foundation models. It demonstrates the broad applications of AI in improving diagnostic consistency, optimizing workflows, and predicting molecular features and prognoses. AI not only enhances the objectivity and efficiency of pathological diagnosis but also promotes the development of emerging interdisciplinary fields such as computational pathomics, providing strong support for precision medicine. Although challenges such as data standardization and regulatory approval remain in clinical implementation, the deep integration of AI and pathology is ushering in a new era of human-machine collaboration and intelligent diagnostics.

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  • 收稿日期:2025-09-29
  • 最后修改日期:2025-11-03
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  • 在线发布日期: 2025-11-25
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