Lipid metabolic reprogramming refers to the adjustments that tumor cells make to their metabolic pathways and gene expression to accommodate changes in energy supply and demand, particularly in the aspects of lipid synthesis, uptake and storage. This reprogramming typically involves a series of complex molecular mechanisms, including the activity of transcription factors, the activation of signaling pathways, and changes in the expression of metabolic enzymes. Clear cell renal cell carcinoma (ccRCC) is the most common subtype of primary renal cell carcinoma, and lipid accumulation within cancer cells is an important histological feature. This phenomenon is closely related to the lipid metabolism reprogramming within ccRCC, which is conducive to meeting the energy demand of ccRCC development, providing oxidative stress protection, and regulating the function of immune cells to avoid immune system attack, but its specific roles and related mechanisms remain poorly understood. This paper reviews the research progress of lipid metabolic reprogramming in ccRCC, aiming to provide new insights for researchers.