基于声学和振动信号的慢性阻塞性肺疾病肺功能评估技术应用与研究进展
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国家重点研发计划(2024YFC3607500),国家自然科学基金(82670051),上海市东方英才计划拔尖项目(BJWS202428),上海市“社区医学与健康管理科研课题研究”专项基金(2024-40),杨浦区卫生健康系统科研课题临床研究专项立项项目(YPM202540),海军军医大学第一附属医院破浪创新人才计划、长风固海计划,海军军医大学第一附属医院临床新技术孵育项目(2024XC105)


Pulmonary function assessment techniques for chronic obstructive pulmonary disease based on acoustic and vibration signals: applications and research progress
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    摘要:

    慢性阻塞性肺疾病(COPD)的肺功能评估日益依赖无创、可及性强的辅助技术。多通道呼吸音分析(MRSA)、肺部超声(LUS)和脉冲振荡技术(IOS)作为三类具有潜力的工具,分别从呼吸音时空特征、肺结构影像学特征和气道力学参数3个维度提供肺功能评估信息。MRSA利用多通道传感器抑制噪声,定位局部通气异常;LUS通过超声实时成像识别肺泡通气状态与间质水肿;IOS基于呼吸阻抗量化气道阻力及肺弹性。临床研究表明,这三类技术在COPD严重程度分级、急性加重预警、病因鉴别及治疗监测中均显示出良好的应用价值。然而,各类技术仍存在标准化不足、设备普及率低、对操作者依赖性较大等挑战。引入人工智能辅助诊断、建立多中心标准化数据库、推动多模态技术融合是未来提升其实用性与可靠性的关键方向。本文围绕上述三类技术的基本原理、临床应用及局限性进行综述,旨在为优化COPD的无创评估体系提供参考。

    Abstract:

    The assessment of pulmonary function in chronic obstructive pulmonary disease (COPD) increasingly relies on non-invasive and highly accessible auxiliary technologies. Multi-channel respiratory sound analysis (MRSA), lung ultrasound (LUS), and impulse oscillometry (IOS) are the 3 promising tools that provide evaluative information from 3 dimensions: spatiotemporal characteristics of respiratory sounds, imaging of lung structure, and airway mechanical parameters, respectively. MRSA uses multi-channel sensors to suppress noise and locate regional ventilation abnormalities; LUS identifies alveolar ventilation status and interstitial edema through real-time ultrasound imaging; and IOS quantifies airway resistance and lung elasticity based on respiratory impedance. Clinical studies have demonstrated considerable clinical value for these 3 technologies in COPD severity grading, early warning of acute exacerbations, etiological differentiation, and treatment monitoring. However, these technologies still face challenges such as insufficient standardization, low device penetration, and significant operator dependence. Introducing artificial intelligence-assisted diagnosis, establishing multi-center standardized databases, and promoting multi-modal technology integration are key directions to improve their practicality and reliability in the future. This review summarizes the principles, clinical applications, and limitations of the aforementioned 3 technologies, aiming to provide a clinical reference for optimizing the non-invasive assessment system for COPD.

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  • 收稿日期:2025-06-19
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  • 在线发布日期: 2026-09-21
  • 出版日期: 2026-09-20
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