| 摘要: |
| 近来,越来越多的证据表明存在线粒体一氧化氮合酶(mitochondrial nitric oxide synthase,mtNOS),它与线粒体内膜的基质面结合,通过钙敏感性途径产生一氧化氮(nitric oxide,NO).生理状态下,mtNOS催化产生的NO通过与细胞色素C氧化酶可逆性竞争来调节线粒体的氧耗和跨膜电位.NO与线粒体呼吸链产生的超氧阴离子反应,生成过氧亚硝酸,后者不可逆性调节线粒体内的敏感靶点,诱导氧化和(或)硝化应激.此外,也发现NO参与了细胞的程序化死亡.本文主要综述了目前关于mtNOS在线粒体功能调节中作用的认识. |
| 关键词: 线粒体、一氧化氮合酶、一氧化氮 |
| DOI：10.3724/SP.J.1008.2006.00656 |
| 投稿时间：2005-12-20修订日期：2006-03-08 |
| 基金项目:国家自然科学基金（30500579）. |
|
| Mitochondrial nitric oxide synthase: biological function |
| 刘文武,孙学军,徐伟刚,LIU Wen-wu,SUN Xue-jun,XU Wei-gang |
| () |
| Abstract: |
| Increasing evidences have shown the existance of a mitochondrial nitric oxide synthase （mtNOS）, which binds to the matrix face of the mitochondrial inner membrane and produces nitric oxide （NO） through a Ca^2＋ sensitive pathway. Under physiological condition, the NO catalyzed by mtNOS regulates mitochondrial oxygen consumption and transmembrane potential via reversible competition with cytochrome C oxidase. The reaction of NO with superoxide anion, which was produced by mitochondrial respiratory chain, yields peroxynitrite. Peroxynitrite irreversibly modifies susceptible targets in mitochondria and induces oxidative and/or nitrative stress. In addition, NO has also been implicated in the programmed cell death. This article reviews the current understanding of mtNOS＇s role in the regulation of mitochondrial functions |
| Key words: mitochondrion nitric oxide synthase nitric oxide |
