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| 离体眼眶肿瘤及正常组织超高场磁共振波谱特点的比较 |
| 陶晓峰,杨根金,王晓钧,魏锐利,肖湘生,施增儒 |
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| (第二军医大学长征医院影像科,上海,200003;第二军医大学药学院分析测试中心,上海,200433;南京工业大学材料科学与工程学院,南京,210009;第二军医大学长征医院眼科,上海,200003) |
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| 摘要: |
| 目的:运用超高场MR系统对离体眼眶肿瘤及正常组织进行体外MRS检测,观察眼眶不同病变类型在超高场磁共振条件下的波谱特点,为MRS波谱分析的临床应用提供理论依据.方法:临床肿瘤标本10例,良性肿瘤7例,恶性肿瘤3例,正常组织标本2例,采用BRUKER AVANCE 400(SB)超高场核磁共振谱仪进行检测,比较各自不同的波谱特点.结果:1H-MRS波谱分析结果表明:从波峰测量和形态上看,眼眶恶性肿瘤Cho和Cr峰值要高于良性肿瘤;良、恶性眼眶肿瘤组织波谱分析在2.0×10-6附近可见到3个连续的单峰,而正常组织均无此波谱现象.结论:1H-MRS 波谱分析能够区分离体眼眶良、恶性肿瘤及正常组织,值得进一步探讨以应用于临床. |
| 关键词: 眼肿瘤、眼眶、超高场磁共振波谱 |
| DOI：10.3724/SP.J.1008.2006.00882 |
| 投稿时间：2005-12-30修订日期：2006-06-05 |
| 基金项目:上海市科委重大项目(034119836),上海市卫生局科委基金(024003). |
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| Comparison of MR spectroscopic characteristics between orbital tumor and normal tissues in vitro by super high field MR |
| TAO Xiao-feng,YANG Gen-jin,WANG Xiao-jun,WEI Rui-li,XIAO Xiang-sheng,SHI Zeng-ru |
| (第二军医大学长征医院影像科,上海,200003;第二军医大学药学院分析测试中心,上海,200433;南京工业大学材料科学与工程学院,南京,210009) |
| Abstract: |
| Objective： To study the MR spectroscopic characteristics of orbital tumors and normal tissues in vitro by the super high field MR, so as to provide theoretical basis for clinical application of MR spectroscopy （MRS）. Methods： Ten tumor specimens （including 7 benign ones and 3 malignant ones） and 2 normal tissue samples received MR spectroscopic examination by BRUKER AVANCE 400（SB）super high field MR, and their MR spectroscopic characteristics were compared. Results： ^1H- MRS with super high field MR showed that the Cho and Cr peaks of malignant orbital tumors were higher than those of benign tumors. Three consecutive single peaks were noticed around 2 × 10^-6 in the MRS of benign and malignant tumors, but not in that of normal tissues. Conclusion： ^1H-MRS can differentiate benign, malignant orbital tumors and normal tissues, making it worth of further study for clinical application. |
| Key words: eye neoplasms orbit MR spectroscopy |
