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| 胺碘酮在预防冠状动脉旁路移植术后房颤中的作用研究 |
| 韩庆奇,沈美芳,徐志云,张宝仁,黄盛东,邹良建,徐激斌,韩林,赵铁军,何斌 |
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| (第二军医大学长海医院胸心外科,上海,200433) |
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| 摘要: |
| 目的:评价胺碘酮在预防冠状动脉旁路移植(CABG)术后房颤(AF)中的作用.方法:184例行常规体外循环(CPB)下CABG患者随机分成实验组和对照组,每组内部又分成60岁以下组和60岁及以上组,实验组术后给予常规药物+胺碘酮,对照组术后给予常规药物+安慰剂.结果:对照组术后AF总发生率明显高于实验组(32.2﹪vs6.4﹪,P＜0.01,OR=7.0).对于60岁以下组,实验组和对照组之间术后AF的发生率无统计学意义,而对于60岁及以上组则存在统计学意义(P＜0.05,P＜0.01).实验组内部60岁以下组和60岁及以上组之间的AF发生率无统计学意义,而对照组内部60岁以下组和60岁及以上组之间的AF发生率则存在统计学意义(P＜0.05,P＜0.01).结论:胺碘酮可以有效预防CABG术后房颤的发生,尤其对于60岁及以上的患者效果更加明显.我们推荐对于60岁及以上的患者,CABG术后应积极应用胺碘酮预防AF的发生. |
| 关键词: 胺碘酮、冠状动脉旁路移植、心房颤动 |
| DOI：10.3724/SP.J.1008.2006.00973 |
| 投稿时间：2006-01-30修订日期：2006-06-23 |
| 基金项目: |
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| Amiodarone in prevention of atrial fibrillation after coronary artery bypass grafting |
| HAN Qing-qi,SHEN Mei-fang,XU Zhi-yun,ZHANG Bao-ren,HUANG Sheng-dong,ZOU Liang-jian,XU Ji-bin,HAN Lin,ZHAO Tie-jun,HE Bin |
| (第二军医大学长海医院胸心外科,上海,200433) |
| Abstract: |
| Objeetive ： To evaluate the role of amiodarone in preventing atrial fibrillation after coronary artery bypass grafting （CABG）. Methods： Totally 184 patients receiving CABG under cardiopulmonary bypass （CPB） were randomly divided into amiodarone group （n= 94） and placebo group （n= 90）, and patients in each group were further divided into ≥ 60 years and 60 years subgroups. Patients in amiodarone group received routine drugs ＋ amiodarone and those in placebo group received routine drugs ＋ placebo. Results： The overall incidence of postoperative AF （paroxysmal and persistent） was significantly higher in the placebo group compared with the amiodarone group （32.20% vs 6.4%, P〈0.01, OR=7.0）. The incidences of postoperative AF were similar in patients aged 〈60 years between the placebo group and the amiodarone group, but were significantly different in patients aged ≥ 60 （P〈0. 05 or P〈0.01）. The postoperative AF incidence was significantly different between 2 age subgroups （P〈0. 05 or P〈0.01） in the placebo group, but not in amiodarone group. Conclusion： Amiodarone can effectively prevent post-operative AF, especially for patients aged ≥ 60 years. Amiodarone should be recommended to patients re- ceiving CABG who aged ≥ 60 years |
| Key words: amiodarone coronary artery bypass atrial fibrillation |
