| 摘要: |
| HH(Hedgehog)信号通路首先发现于果蝇胚胎体节发育调节中,后来陆续在脊椎动物(包括人类)中分离出果蝇HH信号通路中的相关基因.研究发现,HH信号通路不仅调控胚胎时期各胚层组织发育,而且与肿瘤生成密切相关.Gli作为脊椎动物HH信号通路中的锌指核转录因子,与HH信号通路中下游基因的特定序列结合,直接调控HH信号通路目的基因的转录表达,在HH信号通路调控中起核心作用.本文就Gli的在HH信号中的作用机制及可能应用于肿瘤治疗的前景等作简要概述. |
| 关键词: Gli、HH信号通路、肿瘤、治疗学 |
| DOI：10.3724/SP.J.1008.2007.00098 |
| 投稿时间：2006-11-15修订日期：2007-01-04 |
| 基金项目: |
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| Role of Gli in Hedgehog signaling pathway and its prospect in anti-tumor therapy |
| GU Yan-ping,GAO Jun,LI Zhao-shen |
| (第二军医大学长海医院消化内科,上海,200433) |
| Abstract: |
| Hedgehog （HH） signaling pathway was firstly discovered in the regulation of embryonic segments development in Drosophila; later, the biochemical and functional homologs of Drosophila HH signaling genes were also isolated in vertebrates （including human）. Researchers found that HH signaling not only controls the embryonic development, but also plays an important role in tumorigenesis, Gli, a zinc finger transcription factor in the vertebral HH signaling pathway, combines to the special sequences of distal HH targeted genes and directly controls the transcription of targeted genes, playing a key role in HH signaling pathway. In this article, we summarize the role of Gli in HH signaling pathway and its prospect in cancer therapy |
| Key words: Gli Hedgehog signaling pathway neoplasms therapeutics |
