| 摘要: |
| 目的：研究磁性聚乳酸-羟基乙酸氧化酚砷纳米微粒（M-PLGA-PAO-NP）的制备工艺，并对纳米粒子进行评价。方法：运用超声乳化-溶剂挥发法制备磁性聚乳酸-羟基乙酸氧化酚砷纳米微粒，通过透射电镜（TEM）观察微粒形态，振动样品磁强计（VSM）确证纳米微粒磁性的存在，并对纳米微粒的平均粒径、载药量、包封率等进行评价。结果：纳米微粒外观呈规则球形，粒径在140～00nm占总数的80％，载药量为3．2％，包封率为34．2％，药物磁性较好。结论：获得了较满意的磁性聚乳酸-羟基乙酸氧化酚砷纳米微粒制备工艺，其过程简单，粒子性状符合要求。[著者文摘] |
| 关键词: 氧化酚砷 聚乳酸-羟基乙酸 磁性 纳米粒 |
| DOI：10.3724/SP.J.1008.2006.01355 |
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| 基金项目:国家自然科学基金（30370644）;上海科研计划项目（0352nm107）. |
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| Preparation and characterization of magnetic poly D,L-lactide-co-glycolide phenylarsine oxide nanoparticles |
| DONG Qin , CAI Hong-pei , ZHANG Zhong-bing, GAO Shen |
| (1. Department of Gastroenterology, Changzheng Hospital, Second Military Medical University, Shanghai 200003, China ; 2. Department of Pharmaceutics, School of Pharmacy,Second Military Medical University, Shanghai 200433) |
| Abstract: |
| Objective： To study the preparation technique for magnetic poly D,L-lactide-co-glycolide phenylarsine oxide nanoparticles （M-PLGA-PAO-NPs） and to characterize the resultant product. Methods： M-PLGA-PAO-NPs were prepared by using emulsion-evaporation process. The morphology of the prepared nanoparticles were observed by transmission electron microscope and the magnetism of the particles was determined by vibrating sample magnetometer. Meanwhile, we also evaluated the mean diameter, encapsulation ratio, and drug loading rate of the particles. Results： The nanoparticles had a regular spherical surface, with 80% of them having a diameter of 140-500 nm. We also found that the drug loading rate of the particles was 3.2% and the mean encapsulation ratio was 34. 2%. The drug had satisfactory magnetic property. Conclusion： Our method can obtain M-PLGA-PAO-NP with satisfactory quality, it is simple-to-use and the prepared particles can meet the requirement of pharmaceutics.[著者文摘] |
| Key words: phenylarsine oxide poly D, L-lactic-co-glycolic acid magnetite nanoparticle |
