| 摘要: |
| 过氧化物酶体增殖物激活受体（peroxisome proliferator-activated receptor，PPAR）属于核受体超家族成员，可分为三种亚型（PPARα、PPARβ／δ、PPARγ），PPARγ在脂肪形成、脂质代谢、胰岛素敏感性、炎症反应、动脉粥样硬化、血压调节等方面发挥重要作用，本文将就其与糖尿病肾病的关系作一综述。[著者文摘] |
| 关键词: 糖尿病肾病 PPARγ 噻唑烷二酮类 |
| DOI：10.3724/SP.J.1008.2006.01372 |
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| 基金项目: |
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| Peroxisome proliferator-activated receptor-alpha and diabetic nephropathy |
| HUANG Jie-li, YUAN Ai-hong |
| (Department of Nephrology, Tongji Hospital, Tongji University, Shanghai 200065, China) |
| Abstract: |
| Peroxisome proliferator-activated receptor （PPAR）, a member of nuclear hormone receptor superfamily, has 3 subtypes, namely, PPARα, PPARβ/δ, and PPARγ; among them PPARγ plays an important role in adipogenesis, lipid metabolism, insulin sensitivity, inflammation, atherosclerosis, and blood pressure controlling. This article reviews the relationship between PPARγ and diabetic nephropathy.[著者文摘] |
| Key words: diabetic nephropathies PPAR gamma thiazolidinediones |
