| 摘要: |
| 目的：观察非小细胞肺癌（NSCLC）组织中表皮生长因子受体（EGFR） 和血管内皮生长因子（VEGF）的表达，并探讨二者可能的临床意义。方法：免疫组织化学染色比较82例NSCLC和20例非恶性肺组织中EGFR和VEGF的表达；观察NSCLC患者不同临床病理特征下EGFR和VEGF蛋白的表达情况，并分析二者表达的相关性。结果：NSCLC组织中EGFR、VEGF阳性表达率明显高于非恶性肺组织（53.66% vs 0, 62.20% vs 25％, P<0.05）。EGFR表达在不同性别、不同病理类型(鳞癌vs 腺癌)、有无淋巴结转移及不同TNM分期的NSCLC患者之间有统计学差异（P<0.05）；VEGF表达在有无淋巴结转移及不同TNM分期的NSCLC患者之间有统计学差异（P=0.000 1）。EGFR、VEGF高表达患者生存期短于各自的低表达患者（P<0.05）。NSCLC组织中EGFR和VEGF的表达具有相关性（rs=0.314，P<0.05）。结论：NSCLC组织中EGFR和VEGF存在过度表达，二者表达具有相关性，可作为判断NSCLC患者病情及预后的参考指标和靶向治疗靶点。 |
| 关键词: 表皮生长因子受体 血管内皮生长因子 非小细胞肺癌 |
| DOI：10.3724/SP.J.1008.2008.00072 |
| 投稿时间：2007-07-03修订日期：2007-12-25 |
| 基金项目: |
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| Expression of epidermal growth factor receptor and vascular endothelial growth factor in non-small cell lung cancer and its clinical significance |
| ZHAO Xue-wei1*, SUN Guang-yuan1, LI Bing2, XU Zhi-fei1, HE Jin3, LIU Hui-min3 |
| (1.Department of Cardiothoracic Surgery, Changzheng Hospital, Second Military Medical University, Shanghai 200003, China; 2.Department of Respiratory Medicine, Changzheng Hospital, Second Military Medical University, Shanghai 200003; 3.Department of Pathology, Changzheng Hospital, Second Military Medical University, Shanghai 200003) |
| Abstract: |
| Objective：To observe the expression of epidermal growth factor receptor (EGFR) and vascular endothelial growth factor (VEGF) in non-small cell lung cancer(NSCLC), and to discuss its clinical significance. Methods: The expression of EGFR and VEGF was detected in 82 NSCLC and 20 non-malignant pulmonary samples by immunohistochemical method. The expression of EGFR and VEGF in NSCLC patients with various pathological characteristics was observed and the correlation between them was analyzed. Results: The positive rates of EGFR and VEGF in 82 NSCLC samples were obviously higher than those in the 20 non-malignant samples（53.66% vs 0 for EGFR, 62.20% vs 25％ for VEGF, both P<0.05）. The expression of EGFR in NSCLC samples was significantly correlated with the sex of patients, pathological types of cancer (squamous-cell carcinoma vs adenocarcinoma), presence of lymph node metastasis, and TNM stages（P<0.05）. The expression of VEGF in NSCLC was correlated with lymph node metastasis and TNM stages (P<0.05). It was also noticed that higher expression of EGFR or VEGF was associated with poor prognosis of patients (P<0.05). The expression of EGFR was correlated with VEGF expression in pulmonary tissues of NSCLC patients（rs=0.314,P<0.05）. Conclusion: EGFR and VEGF are over-expressed in NSCLC tissues and the 2 are correlated with each other, which may serve as predicator for prognosis and a therapeutic target of NSCLC patients. |
| Key words: epidermal growth fator receptor vascular endothelial growth factor non-small lung cancer |
