| 摘要: |
| 成骨细胞是骨组织中最重要的力学感受细胞和成骨效应细胞。失重环境中骨丢失的主要原因是成骨细胞功能的下降。近年来有关模拟失重条件下成骨细胞的细胞学研究有较大的进展，在成骨细胞的增殖、分化、凋亡、细胞功能及信号转导的变化等方面取得了一系列成果，本文就这些方面的重要研究内容作简要综述。 |
| 关键词: 模拟失重 成骨细胞 细胞学 |
| DOI：10.3724/SP.J.1008.2008.00565 |
| 投稿时间：2007-09-13修订日期：2008-01-17 |
| 基金项目:国家自然科学基金（30300398,30570456,30600132,30700141）. |
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| Osteoblast cytology study in simulated weightless condition：a review |
| WANG Bing,CAO Xin-sheng,ZHANG Shu* |
| (Department of Aerospace Biodynamics，Key Laboratory of Aerospace Medicine of National Education Ministry,The Fourth Military Medical University,Shaanxi 710032,China) |
| Abstract: |
| Osteoblasts are the most important mechanoreceptive and osteogenic cells.The loss of bone in microgravity is mainly due to the dysfunction of osteoblasts.Research on osteoblast cytology under simulated weightlessness has made great progress in recent years. Current experiments are focusing on the changes in the cellular proliferation,differentiation,apoptosis,function and signal transduction in osteoblasts.This paper reviews the progress of the studies in this field. |
| Key words: weightlessness simulation osteoblast cytology |
