| 摘要: |
| 肝细胞癌（hepatocellular carcinoma,HCC）是发病率最高的恶性肿瘤之一，在我国也是癌症导致死亡的主要原因。HCC的早期诊断可显著提高患者生存率。长期以来，血清肿瘤标志物检测用于HCC诊断一直是最有效的方法之一，其中甲胎蛋白（AFP）含量的检测在世界范围内应用最广，但其诊断敏感性和特异性均存在缺陷。寻找HCC特异性标志物一直是相关研究的热点。本文概述了临床常用的多种HCC诊断相关分子。多种新分子的发现有望作为AFP的有效补充，从而提高HCC的诊断率。 |
| 关键词: 癌，肝细胞 诊断 肿瘤标记，生物学 |
| DOI：10.3724/SP.J.1008.2007.01314 |
| 投稿时间：2007-09-18 |
| 基金项目:国家自然科学基金(30770994,30571774). |
|
| Clinical significance of tumor markers for diagnosis of hepatocellular carcinoma |
| WANG Lu,GAO Chun-fang* |
| (Department of Laboratory Medicine,Eastern Hepatobiliary Hospital,Second Military Medical University,Shanghai 200438,China) |
| Abstract: |
| Hepatocellular carcinoma (HCC),one of the most common malignant tumors,is the main cause of cancer death in China.Early diagnosis of the disease is of great importance.Serum tumor markers have been effective for detecting HCC for a long time.Among those markers,alpha fetoprotein (AFP) is the most widely used one in detecting patients with HCC,but it has limited utility for detecting HCC due to its limited sensitivity and specificity.Searching better markers for HCC has been a research focus in recent years.This review introduces many useful markers to supplement AFP for detecting HCC. |
| Key words: carcinoma,hepatocellular diagnosis tumor markers,biological |
