| 摘要: |
| 目的：回顾性分析原发性肝细胞癌（HCC）临床常用实验室指标，寻找与HCC诊断相关的指标。方法：收集828例病理确诊为HCC患者术前检查中的常用肿瘤标志物、血清学生化指标、乙型肝炎病毒（HBV）标志物、HBV DNA滴度等临床实验室数据，分析其与肿瘤大小和肿瘤病理分级之间的相关性。结果：828例中97.7%的患者有HBV感染，其中70.9%的患者伴有不同程度的肝纤维化。HCC患者中肿瘤大小与白蛋白（ALB）、球蛋白（GLB）、白球比（ALB/GLB）、天冬氨酸转氨酶（AST）、AST/ALT、γ-谷氨酰转移酶（GGT）、碱性磷酸酶（ALP）、α-岩藻糖苷酶（AFU）、甲胎蛋白（AFP）、肿瘤分级多项指标有相关性，肿瘤的病理分级（分化程度）与前白蛋白（PALB）、GGT、肿瘤大小有相关性（P＜0.05）。结论：HCC进展与临床实验室多项生化、肿瘤、病毒指标存在相关性，综合应用这些指标对HCC的辅助诊断价值值得进一步研究。 |
| 关键词: N-糖组 癌，肝细胞 电泳，毛细管 |
| DOI：10.3724/SP.J.1008.2007.01280 |
| 投稿时间：2007-09-21修订日期：2007-10-15 |
| 基金项目:国家自然科学基金（30571774）；上海市科学委员会登山计划(064119522). |
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| Expression of N-glycome in sera of patients with hepatocellular carcinoma |
| ZHAO Yun-peng1, GAO Chun-fang1*, FANG Meng1, SUN Shu-han2，LIU Yan1，CHEN Dong-mei1,CAI Mei-lin1 |
| (1.Department of Laboratory Medicine, Eastern Hepatobiliary Hospital, Shanghai 200438,China;2.Department of Medical Genetics, College of Basic Medicine Sciences, Second Military Medical University, Shanghai 200433) |
| Abstract: |
| Objective：To retrospectively analyze the routine clinical laboratory parameters for hepatocellular carcinoma, in an attempt to search for parameters for diagnosis of hepatocellular carcinoma(HCC). Methods: The pre-operation clinical laboratory data, such as tumor makers, and serological biochemical indices, hepatitis B virus (HBV) infection markers, and HBV DNA titers, were collected from 828 patients who were pathologically diagnosed as having HCC; then the correlation between these data with tumor size and the pathological grades of HCC was analyzed. Results:It was found that 97.9% of the 828 patients were infected with HBV and 70.9% of them were accompanied by liver fibrosis. We also found that the tumor size was correlated with albumin (ALB), globulin (GLB), A/G, aspartate aminotransferase (AST), ratio of aspartate to alanine aminotransferase (AST/ALT), gamma-glutamyl transferase (GGT), alkaline phosphatase (ALP), alpha-L-fucosidase (AFU), alpha-fetoprotein (AFP) and tumor grades; meanwhile, the pathological grades of tumor was correlated to prealbumin(PALB), GGT and tumor size(all P＜0.05). Conclusion: The progress of HCC is correlated with several clinical laboratory biochemistry indices and virus indices. The combined application of these indices is worth studying for auxiliary diagnosis of HCC. |
| Key words: N-glycome carcinoma,hepatocellular electrophoresis,capillary |
