| 摘要: |
| 目的：建立可调控式融合固定器(AC-AFF)的实验山羊颈椎模型，并与其他颈椎重建方法的手术时间、出血量以及术后动物进食及恢复活动的时间作比较。方法：18只实验山羊随机分为3组，每组6只，分别施以AC-AFF、钢板+钛网、钢板+髂骨块植入，均切除一个颈椎椎体。详细记录每只山羊手术所用时间、手术中出血量，以及术后开始进食及活动时间，采用方差分析比较各项观察指标的平均值。结果：动物实验中所有山羊均成活，手术切口感染1例，为钛网+钢板组，使用青霉素5 d后痊愈；不全瘫2例，为植骨块+钢板组，前蹄不能站立，不影响跪姿进食，未予特殊处理，1周后开始站立，但行走蹒跚，2周后均完全恢复正常活动。施行C3椎体切除4例(AC-AFF及钛网+钢板组各2例)，其余均为C4椎体切除。统计学比较显示AC-AFF组手术时间最短(P<0.01)，钛网+钢板组及髂骨块+钢板组间无统计学差异；手术中出血量AC-AFF组与钛网+钢板组间无统计学差异，髂骨块+钢板组出血量高于前两组(P<0.01)。结论：AC-AFF较钛网+钢板及髂骨块+钢板操作简便，手术中出血量少，手术时间短，术后动物并发症少，恢复进食及活动早。 |
| 关键词: 可调控式颈椎融合固定器 颈前路钢板 钛网 动物模型 |
| DOI：10.3724/SP.J.1008.2008.00290 |
| 投稿时间：2007-10-30修订日期：2008-01-07 |
| 基金项目: |
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| A goat model for research of anterior cervical-adjustable fusion fixator |
| GUO Yong-fei1,CHEN De-yu1*,LIU Yan1,YUAN Wen1,ZHANG Jing1,WANG Xin-wei1,HU Yu-hua2,LU Xu-hua1,JIA Lian-shun1 |
| (1.Department of Orthopaedics,Changzheng Hospital,Second Military Medical University,Shanghai 200003,China;2.Department of Orthopaedics,Hospital of Armed Police Forces Jiangsu Regional Headquarters,Yangzhou 225003) |
| Abstract: |
| Objective：To establish an animal model for anterior cervical-adjustable fusion fixator (AC-AFF),and to compare the operation time,blood loss，and recovery time of food intake and movement between AC-AFF group and other groups with different cervical reconstruction fixators.Methods: Eighteen goats were evenly randomized into 3 groups: AC-AFF,steel plate+titanium mesh,and steel plate+autogenous iliac bone group.The 3 fixtors were implanted after corpectomy.The operation time,blood loss during operation,and recovery time of food intake and movement were recorded in each animal and were compared.Results: All experiment animals survived after operation; one animal of steel plate+titanium mesh group suffered from incision infection and recovered 5 days after intramuscular penicillin therapy.Two animals in steel plate+autogenous iliac bone group could not stand on forehoof,but food intake was not influenced; the animals could stand 1 week later without treatment and walked with difficulty,and they recovered normal walk 2 weeks later.Four animals received C3 corpectomy (2 received AC-AFF and 2 received steel plate+titanium mesh) and the rest received C4 corpectomy.It was found that AC-AFF group had the shortest operation time (P<0.01),and there was no difference between the other 2 groups.The intra-operation blood loss in the steel plate+autogenous iliac bone group was significantly higher than that in the other 2 groups (P<0.01),with no significant difference found between the latter 2 groups.Conclusion: AC-AFF is easier to manage than the other 2 fixators; besides,AC-AFF has less blood loss,short operation time,less post-operation complication,and early recovery of food intake and movement. |
| Key words: anterior cervical-adjustable fusion fixator cervical plate titanium mesh animal models |
