| 摘要: |
| Notch 信号转导通路对于细胞的生长发育具有广泛影响,主要是通过调控细胞的分化、增殖和凋亡影响正常生长。Notch 信号通路与其他肿瘤发生、发展的关键性通路相互作用。其与肿瘤的相关性最先在由点突变或染色体易位引起的T细胞白血病中确立。随着研究的深入，大量实验证明Notch信号通路的活性变化与其他肿瘤的发生、发展也有密切的关系，如皮肤癌、肝癌、脑肿瘤和乳腺癌等。 Notch 信号通路对一些肿瘤(如脑肿瘤和乳腺癌)起促癌作用,对另外一些(如皮肤癌和肝癌)则体现为抑癌作用，并且与肿瘤干细胞关系密切。另外,Notch 信号通路在同一肿瘤的不同类型或不同发展阶段起的作用也可能不同。 |
| 关键词: Notch 肿瘤干细胞 癌基因 抑癌基因 |
| DOI：10.3724/SP.J.1008.2008.00975 |
| 投稿时间：2007-12-05修订日期：2008-01-31 |
| 基金项目: |
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| Notch signal pathway and tumor |
| LIU Jian,WANG Kui,SHEN Feng* |
| (The First Comprehensive Treatment Department,Eastern Hepatobiliary Hospital,Second Military Medical University,Shanghai 200438,China) |
| Abstract: |
| Notch signal pathway has extensive influence on the growth and development of cells through modulating cell differentiation,proliferation and apoptosis.It also interacts with the key pathways of tumor formation and progression.Its relationship with tumor is initially established through T cell leukemia induced by mismatch or chromosome translocation.Increasing evidence showed that Notch pathway is associated with the formation and progression of the other types of tumor,such as skin cancer,liver cancer,brain tumors and breast cancers.Notch signal pathway has promoting effect on some tumors (such as brain tumors and breast cancer) and inhibitory effect on others (such as skin cancer and liver cancer).Close relationship was found between Notch pathway and tumor stem cells.Moreover,it may have different functions for different subtypes and different stages of one tumor. |
| Key words: Notch Tumor stem cell oncogene tumor suppress gene |
