| 摘要: |
| 目的：研究复合抗肿瘤药物后对磷酸钙骨水泥（calcium phosphate cement,CPC）理化性质的影响。方法：将甲氨蝶呤（MTX）、表柔比星（EPI）、羟基喜树碱（OH-CPT）、三氧化二砷（As2O3）每种药物分别以2%、5%、8%的比例与CPC复合,检测其固化时间、抗压强度及微结构改变。结果：EPI对CPC复合量为2%时显著延长固化时间（P〈0.05）,OH-CPT复合量为5%以及MTX、EPI复合量为8%时CPC最大抗压强度显著下降（P〈0.05）。电镜扫描示药物复合后CPC晶体结构无明显改变。结论：CPC与抗肿瘤药物复合时会导致其理化性质的改变,在临床应用中应做好相关药物复合后的基础研究。[ |
| 关键词: 骨粘合剂 磷酸钙类 抗肿瘤药 理化性质 |
| DOI：10.3724/SP.J.1008.2007.00250 |
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| 基金项目:国家自然科学基金（30400452）. |
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| Physicochemical properties of calcium phosphate cement incorporated with anti-tumor drugs |
| CHEN Hua-jiang, JIA Lian-shun, XIAO Jian-ru, YANG Xing-hai |
| (Department of Orthopeadics, Changzheng Hospital, Second Military Medical University, Shanghai 200003, China) |
| Abstract: |
| Objective：To study the influence of anti-tumor drug incorporation on the physicochemical properties of calcium phosphate cement（CPC）. Methods： Methotrexate （MTX）, epirubicin （EPI）, hydroxy camptothecin （OH-CPT）, and arsenic trioxide （As2O3） were incorporated, each in a proportion of 2%, 5 %, and 8%, into the powder-phase CPC. Untreated CPC was taken as control. The setting time, compression strength, and the microstructure of the resultant products were evaluated and tested. Results： Compared with control group, the setting time was significantly prolonged when 2 % EPI was incorporated into CPC （P〈0.05）, and the maximum compression strength was significantly decreased when 5% OH-CPT and 8% MTX, EPI were incorporated into CPC （P〈0.05）. Electron microscope showed no significant change in the crystal structure after incorporation of the drugs. Conclusion： CPC is an ideal anti-tumor drug delivery material. The changes of physicochemical properties of CPC must be considered when anti-tumor drugs are incorporated into CPC for clinical application.[ |
| Key words: bone cements calcium phosphates antineoplastic agents physicochemical properties |
